Effect Of Different Sodium Hypochlorite Concentrations (%1, %2.5, And %5) On Intracanal Substance P, CGRP, And Opiorphin Levels And Postoperative Pain During Root Canal Retreatment: A Randomized Clinical Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This randomized clinical study aims to evaluate the effect of different sodium hypochlorite concentrations (1%, 2.5%, and 5.25%) used during root canal retreatment on intracanal levels of Substance P, CGRP, and Opiorphin, as well as postoperative pain. Patients requiring non-surgical root canal retreatment will be randomly assigned to one of three irrigation concentration groups. Intracanal samples will be collected before and after irrigation to measure neuropeptide levels. Postoperative pain will be assessed using a visual analog scale (VAS) at predetermined time intervals. The results of this study may help clarify the relationship between irrigant concentration, inflammatory mediators, and postoperative pain following root canal retreatment.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:
• Patients aged between 18 and 65 years.
• Systemically healthy individuals (ASA I or II)
• Patients requiring non-surgical root canal retreatment of a previously treated permanent tooth
• Patients who provide written informed consent.
Locations
Other Locations
Turkey
Atatürk University Faculty of Dentistry, Department of Endodontics
RECRUITING
Erzurum
Contact Information
Primary
KEZBAN MELTEM ÇOLAK, Prof. Dr
meltem25@gmail.com
+905325744027
Time Frame
Start Date:2025-10-01
Estimated Completion Date:2027-02-01
Participants
Target number of participants:60
Treatments
Experimental: 1% Sodium Hypochlorite Irrigation
Participants assigned to this arm will undergo non-surgical root canal retreatment using 1% sodium hypochlorite as the irrigating solution during chemomechanical preparation. Intracanal samples will be collected before and after irrigation to evaluate changes in Substance P, CGRP, and Opiorphin levels. Postoperative pain will be recorded using a visual analog scale (VAS) at predetermined time intervals.
Experimental: 2.5% Sodium Hypochlorite Irrigation
Participants assigned to this arm will undergo non-surgical root canal retreatment using 2.5% sodium hypochlorite as the irrigating solution during chemomechanical preparation. Intracanal samples will be collected before and after irrigation to evaluate changes in Substance P, CGRP, and Opiorphin levels. Postoperative pain will be recorded using a visual analog scale (VAS) at predetermined time intervals.
Experimental: 5% Sodium Hypochlorite Irrigation
Participants assigned to this arm will undergo non-surgical root canal retreatment using 5% sodium hypochlorite as the irrigating solution during chemomechanical preparation. Intracanal samples will be collected before and after irrigation to evaluate changes in Substance P, CGRP, and Opiorphin levels. Postoperative pain will be recorded using a visual analog scale (VAS) at predetermined time intervals.