Periodontitis Clinical Trials

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Efficacy of a Novel Nanoparticle -Augmented Disinfection Protocol in the Non -Surgical Retreatment of Maxillary Anterior Teeth in Type II Diabetic Patients: A Randomized Clinical Trial

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The ultimate biological aim of endodontic therapy is to either prevent or heal apical periodontitis. Root canal treatment can fail for various reasons, such as persistent infection, missing canals, ledges, canal transportation, instrument separation, and perforation. Post-treatment apical periodontitis is an inflammatory response in the tissues surrounding the root tip, triggered by either lingering bacteria from the initial procedure or a new, secondary infection within the canal system. Statistically, this condition affects roughly 5% to 20% of cases where apical periodontitis was present before the initial treatment.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 40
Healthy Volunteers: f
View:

• Diabetic patients type II of either gender aged from 18-40 years

• Permanent mature Maxillary anterior teeth having a baseline periapical lesion (PAI score ≥3).

Locations
Other Locations
Egypt
Minia University, Faculty of Dentistry
RECRUITING
Minya
Contact Information
Primary
Ebthal Hamada Saleh, MSC
ebthalhamada9@gmail.com
+201037570153
Backup
Dalia Ali Ahmed Moukarab, M.D
dalia.mokarab@mu.edu.eg
+201068121523
Time Frame
Start Date: 2026-07-14
Estimated Completion Date: 2027-07-14
Participants
Target number of participants: 28
Treatments
Active_comparator: Non- surgical retreatment Novel Nanoparticle (NSRN)
About 14 cases will be irrigated with 5 ml of Novel Nanoparticle -Augmented irrigation placed in the root canal and activated passively with woodpecker ultrasonic (Guilin Woodpecker Medical Instrument Co., Ltd., China) for 3 cycle 20 seconds.
Active_comparator: Non -surgical root canal retreatment (NSRC)
About 14 cases will be irrigated with 5 ml of (2.5%) NaOCl placed in the root canal and activated passively with woodpecker ultrasonic scaler (Guilin Woodpecker Medical Instrument Co., Ltd., China) for 3 cycle 20 seconds.
Related Therapeutic Areas
Sponsors
Leads: Minia University

This content was sourced from clinicaltrials.gov