Passive Stretching and Dietary Nitrate Rescue Functional Capacity in Peripheral Arterial Disease

Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement, Device
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

Peripheral artery disease (PAD) leads to higher mortality rates and strains healthcare systems due to increased costs. It causes leg pain during walking due to reduced blood flow. Nitric oxide (NO) deficiency contributes to vascular issues in PAD, with few effective treatments available. Passive calf muscle stretching boosts NO levels, vascular health, and walking ability in PAD patients. However, the inflammatory processes underlying these improvements are unclear. This study aims to track inflammatory markers and cardiovascular changes during 12 weeks of passive stretching. Additionally, combining stretching with dietary nitrate could further enhance walking capacity by reducing reactive oxygen species. The study will monitor inflammation, vascular function, and oxidative capacity to understand the effects on functional ability in PAD patients. This research is crucial for improving physical function and addressing exercise intolerance in PAD.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 90
Healthy Volunteers: f
View:

• Ankle-brachial index of 0.90 or less Stable condition for at least 3 months

Locations
United States
Wisconsin
University of Wisconsin La Crosse
RECRUITING
La Crosse
Contact Information
Primary
Jacob T Caldwell, Ph.D.
jcaldwell@uwlax.edu
608-785-8684
Time Frame
Start Date: 2024-05-20
Estimated Completion Date: 2029-12-31
Participants
Target number of participants: 64
Treatments
Experimental: Functional Walking capacity
Passive stretching of the calf muscles 5 days per week for 12-weeks
Experimental: Inflammation
Blood and muscle biopsy samples pre/post passive stretching to assess local and systemic inflammation
Sponsors
Leads: University of Wisconsin, La Crosse

This content was sourced from clinicaltrials.gov