Near-Infrared Diffuse Correlation Spectroscopy to Better Define the Pathophysiology of Peripheral Artery Disease
The goal of this study is to better understand how blood flows and how oxygen is utilized in the lower limbs of people who suffer from peripheral artery disease. This study will also assess how these factors affect treatment outcomes. Specific aims include: Aim 1: Utilize BB-NIR-DCS to differentiate PAD patients experiencing primary oxygen delivery limitations from those suffering from mitochondrial dysfunction. Aim 2: Test the efficacy of BB-NIR-DCS at predicting individual responses to vascular intervention.
• Cases, Aim 1
‣ 18 or older
⁃ willing to participate under the conditions described in the informed consent form (ICF)
⁃ eligible to sign the ICF
⁃ established diagnosis of PAD confirmed by a physician
⁃ able to comply with the study requirements
• Cases, Aim 2
• 1\) completed Aim 1
• Controls 1) asymptomatic, with no history or diagnosis of peripheral artery disease