Find Peripheral Neuropathy Clinical Trials Near You
Use of PEA and Scutellaria in Synergy With Therapeutic Exercise in Chemotherapy-induced Peripheral Neuropathy (CIPN): a Clinical Trial
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
This study aims to find out if taking specific dietary supplements (PEA and Scutellaria) along with therapeutic exercise can help reduce nerve pain and damage caused by chemotherapy. Many cancer patients experience nerve-related side effects from chemotherapy, which can significantly impact their quality of life. The study will observe patients who use these supplements and exercises to see if they can effectively manage and improve their nerve health and reduce pain.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Adults aged 18 years and older.
• Patients who have undergone chemotherapy treatment within the previous 6 months.
• Patients treated with PEA, Scutellaria, and standardized therapeutic exercise according to the EXCAP protocol from April 2025 to September 2025.
• Patients with a washout period from opioid-based analgesic therapy of at least 10 days or who are not receiving opioid-based analgesic therapy.
• Patients presenting with neuropathic pain (NRS ≥ 5).
• Patients able to provide written informed consent.
Locations
Other Locations
Italy
A.O.U.P. P. Giaccone, Palermo, Italia 90127
RECRUITING
Palermo
Contact Information
Primary
Giulia Letizia Mauro
giulia.letiziamauro@unipa.it
+39 0916554160 +39 09165541
Time Frame
Start Date:2025-03-15
Estimated Completion Date:2026-04
Participants
Target number of participants:40
Treatments
PEA + Scutellaria + Therapeutic Exercise
This group consists of patients who will receive a combination of palmitoylethanolamide (PEA) and Scutellaria along with a standardized therapeutic exercise regimen. The goal is to evaluate the synergistic effects of the nutraceuticals and exercise in reducing neuropathic pain and improving overall nerve health.
Therapeutic Exercise Only
Patients in this group will participate in a standardized therapeutic exercise program without any additional nutraceutical intervention. This cohort will help determine the efficacy of therapeutic exercise alone in managing symptoms of chemotherapy-induced peripheral neuropathy (CIPN).
PEA + Scutellaria Only
This group includes patients who will be treated with a combination of PEA and Scutellaria without participating in any structured exercise regimen. The aim is to assess the impact of the nutraceuticals alone on reducing neuropathic pain and improving nerve function.