What is the definition of PHACE Syndrome?

PHACE syndrome is the association of a large hemangioma, usually on the face or neck, in combination with one or more other birth defects. People with PHACE syndrome may have Posterior fossa brain malformations, Hemangioma, Arterial lesions (blood vessel abnormalities in the head or neck), Cardiac (heart) abnormalities/aortic coarctation, and Eye abnormalities. Symptoms and symptom severity may vary from person to person. The cause of the condition is currently unknown. It affects girls much more often than boys. Treatment is based on the signs and symptoms present in the person.


What are the alternative names for PHACE Syndrome?

  • PHACE association
  • PHACES association
  • Posterior fossa brain malformations, hemangiomas of the face, arterial anomalies, cardiac anomalies, and eye abnormalities
  • Pascual-Castroviejo type II syndrome
  • P-CIIS
  • Pascual-Castroviejo syndrome type 2
  • Condition: Sternal Cleft and Segmental Facial Hemangiomas in Children with Phaces Syndrome
  • Journal: Wiadomosci lekarskie (Warsaw, Poland : 1960)
  • Treatment Used: Conservative Management and Surgical Correction
  • Number of Patients: 6
  • Published —
This study determined the risk factors of sternal cleft and segmental facial hemangiomas (red, vascular birthmarks) association in children with PHACES (developmental defects) syndrome.