Planned Delivery at 37 Versus 36 Weeks in Pregnancies Complicated byPlacenta Previa and Accreta: A Randomized Controlled Trial

Status: Recruiting
Location: See all (6) locations...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Current clinical practice guidelines recommend planned cesarean delivery(CD) at 34-37 weeks of gestation in pregnant women with placenta previa and accreta. Preterm birth may lead to neonatal immaturity, while laterCD may increase the risk of severe hemorrhage and surgery complications. Retrospective studies have shown that indicated CD occurs in approximately1/3 of patients before 36 weeks, with the main trigger being antepartum hemorrhage. However, the risk of antepartum hemorrhage is lower after 36 weeks. Recent study showed that delivery shifted from 34-36 weeks to 37 weeks did not increase therisk of maternal intraoperative/postoperative hemorrhage and emergency CD. To further validate this, we propose to conduct a randomized controlled study comparing the effect of planned delivery management strategies at 37 0/7-37 6/7 weeks of gestation with those at 36 0/7-36 6/7 weekson maternal and fetal outcomes. The aim of this study is to explore whether planned delivery up to 37 weeks in pregnant women with placenta previa and accreta improves neonatal outcomes without increasing maternal obstetric risks.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: f
View:

• 28-34 weeks of gestation.

• Both ultrasound and MRI indicate placenta previa with placenta accreta spectrum (PAS).

• Planned to undergo cesarean delivery at the participating study hospitals.

• Agree to participate and sign the informed consent form.

Locations
Other Locations
China
Peking University Third Hospital
NOT_YET_RECRUITING
Beijing
West China Second University Hospital, Sichuan University
NOT_YET_RECRUITING
Chengdu
The First Affiliated Hospital of Chongqing Medical University
NOT_YET_RECRUITING
Chongqing
Guangzhou Women and Children's Medical Center
NOT_YET_RECRUITING
Guangzhou
The Third Affiliated Hospital of Guangzhou Medical University
RECRUITING
Guangzhou
The First Affiliated Hospital of Zhengzhou University
NOT_YET_RECRUITING
Zhengzhou
Contact Information
Primary
Qingwen Nie
nieqingwen@126.com
+86 15622149953
Time Frame
Start Date: 2025-07-12
Estimated Completion Date: 2027-03-01
Participants
Target number of participants: 600
Treatments
Experimental: 37-week group
Subjects were randomized 1:1 at 28-34 weeks. 37-week group: planned delivery at 37 0/7-37 6/7 weeksof gestation.
Active_comparator: 36-week group
Subjects were randomized 1:1 at 28-34 weeks. 36-week group: planned delivery at 36 0/7-36 6/7 weeksof gestation.
Related Therapeutic Areas
Sponsors
Leads: The Third Affiliated Hospital of Guangzhou Medical University

This content was sourced from clinicaltrials.gov