Plaque Psoriasis Clinical Trials

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A Multicenter, Randomized, Double-Blinded, Placebo- Controlled, Dose-Range Finding Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of ORKA-002 in Participants With Moderate-to-Severe Plaque Psoriasis

Status: Recruiting
Location: See all (31) locations...
Intervention Type: Drug, Other
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

This is a multicenter, randomized, double-blinded, placebo-controlled, dose-range finding study to evaluate the efficacy and safety of ORKA-002 in adult participants with moderate-to-severe plaque psoriasis.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 79
Healthy Volunteers: f
View:

• Participants ≥ 18 and \< 80 years of age at the time of consent

• Have a diagnosis of plaque psoriasis for \> 6 months

• Have moderate-to-severe chronic plaque psoriasis defined as:

‣ BSA ≥ 10%, and

⁃ PASI ≥ 12, and

⁃ IGA score of ≥ 3 on a 5-point scale

• Candidate for systemic therapy or phototherapy

• Women of childbearing potential must have a negative pregnancy test

Locations
United States
Alabama
Oruka Therapeutics Investigative Site
RECRUITING
Birmingham
California
Oruka Therapeutics Investigative Site
RECRUITING
Fountain Valley
Oruka Therapeutics Investigative Site
RECRUITING
Los Angeles
Oruka Therapeutics Investigative Site
RECRUITING
San Diego
Oruka Therapeutics Investigative Site
RECRUITING
Santa Ana
Oruka Therapeutics Investigative Site
RECRUITING
Santa Monica
Connecticut
Oruka Therapeutics Investigative Site
RECRUITING
Cromwell
Florida
Oruka Therapeutics Investigative Site
RECRUITING
Coral Gables
Massachusetts
Oruka Therapeutics Investigative Site
RECRUITING
Milford
Michigan
Oruka Therapeutics Investigative Site
RECRUITING
Ann Arbor
Oruka Therapeutics Investigative Site
RECRUITING
Detroit
Oruka Therapeutics Investigative Site
RECRUITING
Warren
Minnesota
Oruka Therapeutics Investigative Site
RECRUITING
New Brighton
North Carolina
Oruka Therapeutics Investigative Site
RECRUITING
Wilmington
Nebraska
Oruka Therapeutics Investigative Site
RECRUITING
Omaha
New York
Oruka Therapeutics Investigative Site
RECRUITING
New York
Ohio
Oruka Therapeutics Investigative Site
RECRUITING
Bexley
Oregon
Oruka Therapeutics Investigative Site
RECRUITING
Portland
Oruka Therapeutics Investigative Site
RECRUITING
Warrenton
Texas
Oruka Therapeutics Investigative Site
RECRUITING
Dallas
Oruka Therapeutics Investigative Site
RECRUITING
Dallas
Washington
Oruka Therapeutics Investigative Site
RECRUITING
Mill Creek
Other Locations
Canada
Oruka Therapeutics Investigative Site
RECRUITING
Barrie
Oruka Therapeutics Investigative Site
RECRUITING
Edmonton
Oruka Therapeutics Investigative Site
RECRUITING
London
Oruka Therapeutics Investigative Site
RECRUITING
North Bay
Oruka Therapeutics Investigative Site
RECRUITING
Peterborough
Oruka Therapeutics Investigative Site
RECRUITING
Saskatoon
Oruka Therapeutics Investigative Site
RECRUITING
Surrey
Oruka Therapeutics Investigative Site
RECRUITING
Toronto
Oruka Therapeutics Investigative Site
RECRUITING
Waterloo
Contact Information
Primary
Oruka Clinical Trials Information
clinicaltrials@orukatx.com
781-560-0299
Time Frame
Start Date: 2026-03-19
Estimated Completion Date: 2029-04
Participants
Target number of participants: 160
Treatments
Experimental: (Induction Period - Arm 1) ORKA-002
Participants will receive ORKA-002 per protocol Induction regimen.
Experimental: (Induction Period - Arm 2) ORKA-002
Participants will receive ORKA-002 per protocol Induction regimen.
Experimental: (Induction Period - Arm 3) ORKA-002
Participants will receive ORKA-002 per protocol Induction regimen.
Placebo_comparator: (Induction Period - Arm 4) Placebo
Participants will receive Placebo per protocol Induction regimen.
Related Therapeutic Areas
Sponsors
Leads: Oruka Therapeutics, Inc.

This content was sourced from clinicaltrials.gov

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