Functional and Structural Impacts of Polycystic Ovary Syndrome (PCOS) on Brain Health
The purpose of this study is to determine how polycystic ovary syndrome (PCOS) impacts overall brain health, such as cerebral blood flow (CBF), brain structure and connectivity, and cognitive performance. 45 reproductive aged (18-45 years) individuals with ovaries, with and without PCOS, will be enrolled to complete brain structure and CBF scans via magnetic resonance imaging (MRI) over 2 testing visits and can expect to be on study for approximately 5 hours over a 1 to 3 month period.
• Rotterdam criteria demonstrating two out of the three criteria. These are:
‣ Presence of clinical hyperandrogenism or biochemical hyperandrogenism
⁃ A history of irregular menstrual cycles
⁃ Presence of polycystic ovarian morphology on ultrasound
• Regular menstrual cycles (not meeting criteria for irregular cycles above)
• No diagnosis of PCOS
• Controls may have isolated hirsutism or polycystic ovaries on ultrasound as long as they do not meet Rotterdam criteria for PCOS