Unmasking Polycythemia Vera in Long-Standing Essential Thrombocythemia: A ELN-Multicenter Study on Phenotypic Evolution and Clinical Outcomes
Status: Recruiting
Location: See all (25) locations...
Study Type: Observational
SUMMARY
International multicenter retrospective observational study consisting of two parts: a nested case-control study (part A) and a comparative retrospective cohort study (part B).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 100
Healthy Volunteers: f
View:
• \- ET patients (diagnosed according to International consensus classification of myeloid neoplasms and acute leukemias - 2022 criteria) who are JAK2V617F positive and have progressed to PV (diagnosed according to International consensus classification of myeloid neoplasms and acute leukemias - 2022 criteria) by 31/12/2020. The date of PV diagnosis will be defined as the index date and this group of patients will be defined as ET-to-PV cases.
Locations
United States
Minnesota
Mayo Clinic
NOT_YET_RECRUITING
Rochester
Other Locations
Germany
University Hospital Halle
NOT_YET_RECRUITING
Halle
Hannover Medical School
NOT_YET_RECRUITING
Hanover
University Clinic for Hematology, Oncology, Hemostaseology and Palliative Care Johannes Wesling Medical Center
NOT_YET_RECRUITING
Minden
Italy
A.S.O. SS. Antonio e Biagio e C.Arrigo, SC Ematologia
NOT_YET_RECRUITING
Alessandria
ASST Papa Giovanni XXIII, SC Ematologia
RECRUITING
Bergamo
ASST-Spedali Civili
NOT_YET_RECRUITING
Brescia
Ospedale Businco
NOT_YET_RECRUITING
Cagliari
AOU Policlinico Vittorio Emanuele - PO Gaspare Rodolico
NOT_YET_RECRUITING
Catania
AOU Careggi, Divisione di Ematologia
NOT_YET_RECRUITING
Florence
ASST Grande Ospedale Metropolitano Niguarda, Divisione di Ematologia
NOT_YET_RECRUITING
Milan
Fondazione IRCCS Cà Grande - Op. Maggiore Policlinico
NOT_YET_RECRUITING
Milan
Ospedale San Raffaele
NOT_YET_RECRUITING
Milan
ASST MONZA Ospedale San Gerardo Clinica Ematologica
NOT_YET_RECRUITING
Monza
Azienda Ospedaliera Universitaria Federico II di Napoli Divisione di Ematologia e Trapianti del Midollo
NOT_YET_RECRUITING
Naples
Azienda Ospedaliero Universitaria Maggiore della Carità di Novara SCDU Ematologia
NOT_YET_RECRUITING
Novara
Divisione Ematologia, Fondazione IRCCS Policlinico San Matteo
NOT_YET_RECRUITING
Pavia
Presidio Ospedaliero di Pescara
NOT_YET_RECRUITING
Pescara
Fondazione Policlinico Universitario Gemelli
NOT_YET_RECRUITING
Roma
Umberto I Policlinico
NOT_YET_RECRUITING
Roma
Azienda Ospedaliera Universitaria Integrata - Ospedale Borgo Roma, Unità di Ematologia
NOT_YET_RECRUITING
Verona
Divisione Ematologia, Ospedale San Bortolo
NOT_YET_RECRUITING
Vicenza
Spain
IDIBAPS, Hospital clinic
RECRUITING
Barcelona
12 Octubre University Hospital
RECRUITING
Madrid
United Kingdom
Guy's and St. Thomas' NHS Foundation Trust
NOT_YET_RECRUITING
London
Contact Information
Primary
TIZIANO BARBUI, MD
tbarbui@fondazionefrom.it
+39 0352675134
Backup
FRANCESCA FENILI
sperimentazioni@fondazionefrom.it
Time Frame
Start Date: 2025-12-01
Estimated Completion Date: 2026-07-31
Participants
Target number of participants: 678
Treatments
ET to PV patients
Patients JAK2V617F positive and who have progressed to PV by 31/12/2020.
ET patients
Patients JAK2V617F positive who did not progress to PV after a comparable period of time. This control group will be selected using a 1:1 matched case-control design.
PV de novo patients
Patients diagnosed with de novo PV (no progression from previous ET). This control group will be recruited using a 1:1 matching procedure.
Related Therapeutic Areas
Sponsors
Leads: FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS