Unmasking Polycythemia Vera in Long-Standing Essential Thrombocythemia: A ELN-Multicenter Study on Phenotypic Evolution and Clinical Outcomes
Status: Recruiting
Location: See all (24) locations...
Study Type: Observational
SUMMARY
International multicenter retrospective observational study consisting of two parts: a nested case-control study (part A) and a comparative retrospective cohort study (part B).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 100
Healthy Volunteers: f
View:
• \- ET patients (diagnosed according to International consensus classification of myeloid neoplasms and acute leukemias - 2022 criteria) who are JAK2V617F positive and have progressed to PV (diagnosed according to International consensus classification of myeloid neoplasms and acute leukemias - 2022 criteria) by 31/12/2020. The date of PV diagnosis will be defined as the index date and this group of patients will be defined as ET-to-PV cases.
Locations
United States
Minnesota
Mayo Clinic
ACTIVE_NOT_RECRUITING
Rochester
Other Locations
Germany
University Hospital Halle
NOT_YET_RECRUITING
Halle
Hannover Medical School
RECRUITING
Hanover
University Clinic for Hematology, Oncology, Hemostaseology and Palliative Care Johannes Wesling Medical Center
RECRUITING
Minden
Italy
A.S.O. SS. Antonio e Biagio e C.Arrigo, SC Ematologia
NOT_YET_RECRUITING
Alessandria
ASST Papa Giovanni XXIII, SC Ematologia
RECRUITING
Bergamo
Policlinico S. Orsola - Malpighi
NOT_YET_RECRUITING
Bologna
ASST-Spedali Civili
NOT_YET_RECRUITING
Brescia
AOU Careggi, Divisione di Ematologia
RECRUITING
Florence
ASST Grande Ospedale Metropolitano Niguarda, Divisione di Ematologia
NOT_YET_RECRUITING
Milan
Fondazione IRCCS Cà Grande - Op. Maggiore Policlinico
NOT_YET_RECRUITING
Milan
Ospedale San Raffaele
NOT_YET_RECRUITING
Milan
ASST MONZA Ospedale San Gerardo Clinica Ematologica
NOT_YET_RECRUITING
Monza
Azienda Ospedaliera Universitaria Federico II di Napoli Divisione di Ematologia e Trapianti del Midollo
NOT_YET_RECRUITING
Naples
Azienda Ospedaliero Universitaria Maggiore della Carità di Novara SCDU Ematologia
RECRUITING
Novara
Divisione Ematologia, Fondazione IRCCS Policlinico San Matteo
NOT_YET_RECRUITING
Pavia
Presidio Ospedaliero di Pescara
NOT_YET_RECRUITING
Pescara
Fondazione Policlinico Universitario Gemelli
RECRUITING
Roma
Umberto I Policlinico
NOT_YET_RECRUITING
Roma
Azienda Ospedaliera Universitaria Integrata - Ospedale Borgo Roma, Unità di Ematologia
NOT_YET_RECRUITING
Verona
Divisione Ematologia, Ospedale San Bortolo
RECRUITING
Vicenza
Spain
IDIBAPS, Hospital clinic
RECRUITING
Barcelona
12 Octubre University Hospital
RECRUITING
Madrid
United Kingdom
Guy's and St. Thomas' NHS Foundation Trust
RECRUITING
London
Contact Information
Primary
TIZIANO BARBUI, MD
tbarbui@fondazionefrom.it
+39 0352675134
Backup
FRANCESCA FENILI
sperimentazioni@fondazionefrom.it
Time Frame
Start Date: 2025-12-01
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 678
Treatments
ET to PV patients
Patients JAK2V617F positive and who have progressed to PV by 31/12/2020.
ET patients
Patients JAK2V617F positive who did not progress to PV after a comparable period of time. This control group will be selected using a 1:1 matched case-control design.
PV de novo patients
Patients diagnosed with de novo PV (no progression from previous ET). This control group will be recruited using a 1:1 matching procedure.
Related Therapeutic Areas
Sponsors
Leads: FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS