Investigating the Potential for Musculoskeletal Tissues and Cells Isolated From Juvenile Patients in the Development of Novel Therapies for Cartilage and Bone Injury and Osteoarthritis

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The goal of this observational study is to analyse the cartilage and bone forming potential of cells isolated from the tissues of patients undergoing surgery for the treatment of polydactyly, hip dislocation and from other bio-banked cartilage tissues. The main question it aims to answer is: Which of the following tissues from polydactyly digit, iliac apophysis or other bio-banked cartilage produce better cartilage in vitro and in vivo? Participants receiving digit amputation surgery for treatment of polydactyly will be asked to donate the associated waste tissue whilst participants receiving surgery to treat a dislocated hip will be asked to donate an extra small piece of cartilage tissue (approximately 1 gram) from the iliac apophysis. Other tissues for the study will be obtained from those donated to biobanks.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: t
View:

⁃ For juvenile/infant donors:

• Parents/guardians being able to provide signed and dated informed consent form.

• Scheduled for one of the following surgical treatments:

⁃ Digit amputations due to polydactyly. Surgery to treat dislocated hips.

⁃ For biobank/NHSBT donors

• Informed consent via consenting institution.

Locations
Other Locations
United Kingdom
Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
RECRUITING
Oswestry
Contact Information
Primary
Karina T Wright, PhD
karina.wright1@nhs.net
+441691404022
Backup
Sharon J Owen, PhD
sharon.owen12@nhs.net
+441691404295
Time Frame
Start Date: 2018-10-08
Estimated Completion Date: 2037-09-01
Participants
Target number of participants: 325
Related Therapeutic Areas
Sponsors
Collaborators: NHS Blood and Transplant, Norfolk and Norwich University Hospitals NHS Foundation Trust, Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust, Scottish National Blood Transfusion Service, Birmingham Women's and Children's NHS Foundation Trust, University of Birmingham, Alder Hey Children's NHS Foundation Trust, The Royal Orthopaedic Hospital NHS Trust, Royal National Orthopaedic Hospital NHS Trust
Leads: Keele University

This content was sourced from clinicaltrials.gov

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