PolymicrogyriaSymptoms, Doctors, Treatments, Advances & More
Polymicrogyria Overview
Learn About Polymicrogyria
Polymicrogyria is characterized by abnormal development of the brain before birth. The surface of the brain normally has many ridges or folds, called gyri. In people with polymicrogyria, the brain develops too many folds, and the folds are unusually small. The name of this condition literally means too many (poly-) small (micro-) folds (-gyria) on the surface of the brain.
In most people with polymicrogyria, the cause of the condition is unknown. However, researchers have identified several environmental and genetic factors that may contribute to the development of this disorder.
Although the prevalence of polymicrogyria is unknown, it is one of the most common malformations of cortical development, which are malformations that affect the development of the outer surface of the brain (cerebral cortex).
It can be difficult to determine the cause and inheritance pattern of polymicrogyria. The condition can be inherited in different ways depending on the particular cause.
Boston Children's Hospital
Annapurna Poduri is a Neurologist practicing medicine in Boston, Massachusetts. Dr. Poduri is rated as an Elite provider by MediFind in the treatment of Polymicrogyria. She is also highly rated in 52 other conditions, according to our data. Her clinical expertise encompasses West Syndrome, Epilepsy, Polymicrogyria, and Cortical Dysplasia.
Division Of Newborn Medicine
Patricia Grant is a Pediatrics provider practicing medicine in Boston, Massachusetts. Dr. Grant is rated as an Elite provider by MediFind in the treatment of Polymicrogyria. She is also highly rated in 4 other conditions, according to our data. Her clinical expertise encompasses Polymicrogyria, Cortical Dysplasia, Hydrocephalus, and Corpus Callosum Agenesis.
Fairview Express Care
William Dobyns is a Medical Genetics specialist and a Pediatrics provider practicing medicine in Minneapolis, Minnesota. He has been practicing medicine for over 48 years. Dr. Dobyns is rated as an Elite provider by MediFind in the treatment of Polymicrogyria. He is also highly rated in 46 other conditions, according to our data. His clinical expertise encompasses Increased Head Circumference, Lissencephaly, Cerebellar Hypoplasia, and Cortical Dysplasia. Dr. Dobyns is currently accepting new patients.
Summary: This is a 3-part Phase 2 randomized study evaluating the safety and efficacy of the mutant-selective PI3Kα inhibitor, zovegalisib (RLY-2608), in adults and children with PIK3CA Related Overgrowth Spectrum (PROS) and malformations driven by PIK3CA mutation. Part 1 is a dose selection, Part 2 is a basket design with exploratory single-arm cohorts for various subpopulations of participants, and Part ...
Summary: This study is a two periods multi-center Phase II trial, with a 6 months double-blind, placebo-controlled period followed by open label period, to assess the efficacy and safety of alpelisib (BYL719) in pediatric and adult patients with Megalencephaly-CApillary malformation Polymicrogyria syndrome (MCAP)
Published Date: June 16, 2026
Published By: National Institutes of Health