Condition 101 About Polymyalgia Rheumatica

What is the definition of Polymyalgia Rheumatica?

Polymyalgia rheumatica (PMR) is an inflammatory disorder. It involves pain and stiffness in the shoulders and often the hips.

What are the alternative names for Polymyalgia Rheumatica?

PMR

What are the causes for Polymyalgia Rheumatica?

Polymyalgia rheumatica most often occurs in people over 50 years old. The cause is unknown.

PMR may occur before or with giant cell arteritis (GCA; also called temporal arteritis). This is a condition in which blood vessels that supply blood to the head and eye become inflamed.

PMR can sometimes be hard to tell apart from rheumatoid arthritis (RA) in an older person. This occurs when tests for rheumatoid factor and anti-CCP antibody are negative.

What are the symptoms for Polymyalgia Rheumatica?

The most common symptom is pain and stiffness in both shoulders and the neck. The pain and stiffness are worse in the morning. This pain most often progresses to the hips.

Fatigue is also present. People with this condition find it increasingly hard to get out of bed and to move around.

Other symptoms include:

  • Appetite loss, which leads to weight loss
  • Depression
  • Fever

What are the current treatments for Polymyalgia Rheumatica?

Without treatment, PMR does not get better. However, low doses of corticosteroids (such as prednisone, 10 to 20 mg per day) can ease symptoms, often within a day or two.

  • The dose should then be slowly reduced to a very low level.
  • Treatment needs to continue for 1 to 2 years. In some people, even longer treatment with low doses of prednisone is needed.

Corticosteroids can cause many side effects such as weight gain, development of diabetes or osteoporosis. You need to be watched closely if you are taking these medicines. If you are at risk for osteoporosis, your health care provider may recommend you take medicines to prevent this condition.

What is the outlook (prognosis) for Polymyalgia Rheumatica?

For most people, PMR goes away with treatment after 1 to 2 years. You might be able to stop taking medicines after this point, but check with your provider first.

For some people, symptoms return after they stop taking corticosteroids. In these cases, another medicine such as methotrexate or tocilizumab may be needed.

Giant cell arteritis may also be present or can develop later. If this is the case, the temporal artery would need to be evaluated.

More severe symptoms can make it harder for you to work or take care of yourself at home.

When should I contact a medical professional for Polymyalgia Rheumatica?

Call your provider if you have weakness or stiffness in your shoulder and neck that does not go away. Also contact your provider if you have new symptoms such as fever, headache, and pain with chewing or loss of vision. These symptoms may be from giant cell arteritis.

How do I prevent Polymyalgia Rheumatica?

There is no known prevention.

REFERENCES

Dejaco C, Singh YP, Perel P, et al. 2015 recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. Arthritis Rheumatol. 2015;67(10):2569-2580. PMID: 2635874 www.ncbi.nlm.nih.gov/pubmed/26352874.

Hellmann DB. Giant cell arteritis, polymyalgia rheumatica, and Takayasu's arteritis. In: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelley and Firestein's Textbook of Rheumatology. 10th ed. Philadelphia, PA: Elsevier; 2017:chap 88.

Kermani TA, Warrington KJ. Advances and challenges in the diagnosis and treatment of polymyalgia rheumatica. Ther Adv Musculoskelet Dis. 2014;6(1):8-19. PMID: 24489611 www.ncbi.nlm.nih.gov/pubmed/24489611.

Salvarani C, Ciccia F, Pipitone N. Polymyalgia rheumatica and giant cell arteritis. In: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Rheumatology. 7th ed. Philadelphia, PA: Elsevier; 2019:chap 166.

Top Global Doctors For Polymyalgia Rheumatica

Latest Advances On Polymyalgia Rheumatica

  • Condition: Giant Cell Arteritis
  • Journal: Arthritis research & therapy
  • Treatment Used: Tocilizumab
  • Number of Patients: 60
  • Published —
In this study, researchers evaluated the safety and effectiveness of tocilizumab for the treatment of giant cell arteritis.
  • Condition: Polymyalgic complaint
  • Journal: Deutsche medizinische Wochenschrift (1946)
  • Treatment Used: Complete Tumor Resection
  • Number of Patients: 1
  • Published —
This case report describes a 61-year-old caucasian male diagnosed with polymyalgia rheumatica treated with 20?mg prednisone/day, after which MRI revealed a retroperitoneal liposarcoma that was treated with complete tumor resection.

Clinical Trials For Polymyalgia Rheumatica

Clinical Trial
  • Status: Not yet recruiting
  • Phase: N/A
  • Intervention Type: Procedure
  • Participants: 20
  • Start Date: January 2021
Beyond Analysis Of Blood Sample, to Approach Immunopathology of Polymyalgia Rheumatica on Shoulder Bursae's Biopsies: the BAOBAB Study
Clinical Trial
  • Status: Recruiting
  • Phase: Phase 2
  • Intervention Type: Drug
  • Participants: 34
  • Start Date: December 1, 2020
BAriCitinib Healing Effect in earLy pOlymyalgia Rheumatica (BACHELOR Study)