Exposure and Response Prevention to Improve Functioning in Veterans With Obsessive Compulsive Disorder

Status: Recruiting
Location: See all (18) locations...
Intervention Type: Behavioral, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness impacting work, social, and family functioning. Exposure and Response Prevention (ERP) is the sole evidence-based psychotherapy for OCD; however, no randomized controlled trials (RCTs) have examined the effectiveness of ERP among Veterans or individuals with both OCD and posttraumatic stress disorder (PTSD). This 4-year Hybrid Type I trial will compare outcomes of ERP to those of a control condition among Veterans with OCD. Primary and secondary aims will examine whether Veterans' functioning, quality of life, and OCD symptoms differ between the ERP and control in the full sample of Veterans with OCD, and in the half of the sample with both OCD and PTSD. The tertiary aim is to conduct a mixed-methods formative evaluation of the implementation potential of ERP in VA mental health settings.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Veterans having a primary diagnosis of Obsessive Compulsive Disorder (OCD)(50% of sample) and comorbid OCD and Post-traumatic stress disorder (PTSD) (50% of sample) who are receiving care from the Michael E. DeBakey VA Medical Center (MEDVAMC) in Houston, TX; the Ralph H. Johnson VA Medical Center in Charleston, SC; the VISN 20 Clinical Resource Hub which provides telehealth services to Washington, Oregon, and Alaska: the VISN 2 Clinical Resource Hub which provides telehealth services to New Jersey, New York, and northern Pennsylvania, and the VISN 6 Clinical Resource Hub which provides telehealth services to North Carolina and Virginia.

• Willingness to participate in Exposure and Response Prevention(ERP)

Locations
United States
North Carolina
Asheville VA Medical Center, Asheville, NC
RECRUITING
Asheville
Durham VA Medical Center, Durham, NC
RECRUITING
Durham
Fayetteville VA Medical Center, Fayetteville, NC
RECRUITING
Fayetteville
Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC
RECRUITING
Salisbury
New Jersey
East Orange Campus of the VA New Jersey Health Care System, East Orange, NJ
RECRUITING
East Orange
New York
VA Western New York Healthcare System, Buffalo, NY
RECRUITING
Buffalo
VA NY Harbor Healthcare System, New York, NY
RECRUITING
New York
Northport VA Medical Center, Northport, NY
RECRUITING
Northport
James J. Peters VA Medical Center, Bronx, NY
RECRUITING
The Bronx
Oregon
VA Roseburg Healthcare System, Roseburg, OR
RECRUITING
Roseburg
VA Southern Oregon Rehabilitation Center and Clinics, White City, OR
RECRUITING
White City
South Carolina
Ralph H. Johnson VA Medical Center, Charleston, SC
RECRUITING
Charleston
Texas
Michael E. DeBakey VA Medical Center, Houston, TX
RECRUITING
Houston
Virginia
Hampton VA Medical Center, Hampton, VA
RECRUITING
Hampton
Hunter Holmes McGuire VA Medical Center, Richmond, VA
RECRUITING
Richmond
Salem VA Medical Center, Salem, VA
RECRUITING
Salem
Washington
Spokane VA Medical Center, Spokane, WA
RECRUITING
Spokane
Jonathan M. Wainwright Memorial VA Medical Center, Walla Walla, WA
RECRUITING
Walla Walla
Contact Information
Primary
Matthew G Escamilla, BS
matthew.escamilla@va.gov
(713) 440-4461
Backup
Terri L Fletcher, PhD
Terri.Fletcher@va.gov
(713) 440-4400
Time Frame
Start Date: 2022-10-03
Estimated Completion Date: 2026-05-31
Participants
Target number of participants: 160
Treatments
Experimental: Exposure and Response Prevention (ERP)
ERP will be based upon the Treatments That Work series, which contains both a provider manual and client workbook. Sessions will last 90 minutes and occur weekly for 16 sessions. All ERP treatment will be delivered via VTH. Participants will receive instructions on accessing the VTH platform and take part in a brief practice run connecting to the VTH appointment with guidance from an RA. ERP treatment content includes psychoeducation about OCD, assessment of OCD symptoms, the rationale for treatment, construction of a hierarchy or a list of feared or avoided situations, and in-session in-vivo and imaginal exposures. Weekly homework assignments will include self-monitoring, reading chapters about the treatment, and practicing exposures daily. All therapy sessions will be audio-recorded. Although sessions are expected to occur weekly, accounting for delays due to scheduling, holidays, and missed appointments, the investigators will allow up to 6 months to complete the treatment.
Other: Control Condition
Participants randomized to the control condition will receive 16 weekly sessions of stress management training via video telehealth. This control condition was chosen because it is expected to provide the therapeutic alliance and common factors associated with therapy generally and some specific effects in anxiety reduction.
Sponsors
Leads: VA Office of Research and Development

This content was sourced from clinicaltrials.gov

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