Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD
Who is this study for? Adult veterans with post-traumatic stress disorder
What treatments are being studied? Repetitive transcranial magnetic stimulation
Status: Recruiting
Location: See all (3) locations...
Intervention Type: Device, Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The purpose of this study is to examine the benefits of combining repetitive Transcranial Magnetic Stimulation (rTMS) coupled with Cognitive Processing Therapy (CPT) in treating combat-related Posttraumatic Stress Disorder (PTSD) symptoms. The study will also examine change in depression, psychosocial functioning, and neurophysiological (i.e., electroencephalography and magnetic resonance images) measures.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: f
View:
• Veterans of Post-9/11 military conflicts
• with diagnosis of PTSD based on CAPS-5 related to Post-9/11 military combat
Locations
United States
Florida
Florida State University College of Medicine
RECRUITING
Tallahassee
Texas
Metrocare Services of Dallas
RECRUITING
Addison
The University of Texas at Dallas
RECRUITING
Dallas
Contact Information
Primary
Elizabeth Ellen Morris, PhD
neurolab@utdallas.edu
214-883-3171
Backup
Jill Ritter, BS
neurolab@utdallas.edu
972-883-3171
Time Frame
Start Date: 2019-05-01
Estimated Completion Date: 2026-07-31
Participants
Target number of participants: 330
Treatments
Sham_comparator: Sham rTMS + CPT
30 minutes of sham repetitive transcranial magnetic stimulation (rTMS) to the right dorsolateral prefrontal cortex (rDLPFC) prior to each Cognitive Processing Therapy (CPT) session
Active_comparator: Active rTMS + CPT
30 minutes of 1 Hz rTMS to rDLPFC prior to each CPT session
Active_comparator: Active rTMS Alone
30 minutes of 1 Hz rTMS to rDLPFC at 1 session per week over 12 weeks
Authors
Amy Williams
Related Therapeutic Areas
Sponsors
Collaborators: Florida State University, Metrocare Services of Dallas, Johns Hopkins University, University of Texas Southwestern Medical Center
Leads: The University of Texas at Dallas