Neuromodulation of the Fear Extinction Circuit Using Temporally and Anatomically Specific TMS in Humans

Status: Recruiting
Location: See location...
Intervention Type: Behavioral, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study aims to explore the mechanisms of how transcranial magnetic stimulation (TMS) impacts fear circuits. The overarching objectives are to understand how varying TMS parameters affect targeted brain regions in order to optimize its impact on enhancing fear extinction memory consolidation in a population with known fear extinction deficiencies: post-traumatic stress disorder (PTSD). 250 subjects will take part in this research study across UTHealth Houston. The study will include preliminary screenings, baseline visits, and experimental visits across four days

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: t
View:

• Willing and able to provide informed consent.

• Inclusion Criteria for PTSD Subjects - Diagnosis of current PTSD

• Inclusion Criteria: Healthy Controls (HC) - no current psychiatric disorders (Axis I disorders)

Locations
United States
Texas
UTHealth Houston
RECRUITING
Houston
Contact Information
Primary
Mohammed Milad, PhD
Mohammed.R.Milad@uth.tmc.edu
713-486-2754
Backup
Isabel Moallem, PhD
B.Isabel.Moallem@uth.tmc.edu
Time Frame
Start Date: 2022-02-01
Estimated Completion Date: 2027-09-30
Participants
Target number of participants: 250
Treatments
Experimental: Fear Conditioning and Extinction Paradigm, plus Transcranial Magnetic Stimulation (TMS)
Participants will undergo a 3-day experimental paradigm. On day 1, participants will undergo a resting-state and structural scans in the fMRI scanner. The data from this scan will be used to determine the specific location of the TMS target for each participant. And participants will be aversively conditioned to two cues in the fMRI scanner. Task based and resting-state scans will occur on this day.~On day 2, subjects will undergo extinction training outside of the scanner where one of the conditioned cues will be paired with TMS in a temporally and anatomically specific manner. A resting-state scan will occur before and after inside the scanner.~On day 3, conditioned cues will be presented during the extinction recall phase of the study. This phase will be conducted in the fMRI scanner. Task-based and resting-state scans will occur on this day.
Authors
Mohammed Milad
Related Therapeutic Areas
Sponsors
Collaborators: National Institute of Mental Health (NIMH)
Leads: The University of Texas Health Science Center, Houston

This content was sourced from clinicaltrials.gov

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