Post-Traumatic Stress Disorder (PTSD) Clinical Trials

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Forgetting Fear: Establishing a Novel Non-invasive Approach to Disrupt Fear-based Sensory Memory Consolidation in Humans

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This project represents a unique collaborative opportunity to pursue the essential proof-of-principle demonstration that non-invasive interference of sensory cortical memory consolidation shortly after an emotional experience can attenuate the cued fear response and potentially reduce the risk of developing post-traumatic stress disorder (PTSD). If successful, the study results would anchor a potential advance in the treatment of patients after a traumatic event and seed future animal and clinical studies of emotional sensory cortical memory consolidation to reduce the prevalence and negative sequelae of PTSD.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• Ability to provide informed consent

• Willingness to participate in study

• No history of musculoskeletal impairment or neurological disease

• Clinical diagnosis of PTSD for individuals in the PTSD group.

Locations
United States
Georgia
Emory Rehabilitation Hospital
RECRUITING
Atlanta
Emory University Hospital
RECRUITING
Atlanta
Contact Information
Primary
Michael Borich, PhD
michael.borich@emory.edu
404-712-5512
Backup
Jennifer Stevens, PhD
jswils4@emory.edu
404-778-1698
Time Frame
Start Date: 2022-11-28
Estimated Completion Date: 2028-12
Participants
Target number of participants: 66
Treatments
Experimental: cTBS: Inhibitory Transcranial magnetic stimulation (TMS) to sensory Cortex
Participants will undergo a Functional magnetic resonance imaging (fMRI) scan while performing a fear conditioning/extinction task at the Center for Systems Imaging- Emory University Hospital (CSI-EUH) and then either stay at CSI-EUH or relocate to the Neural Plasticity Research Laboratory at Emory Rehabilitation Hospital. Participants will then be randomly assigned to either receive active or sham continuous theta burst stimulation (cTBS) to transiently disrupt neural activity in the targeted sensory cortex region specifically during the sensory memory consolidation window.
Placebo_comparator: Sham cTBS
Participants will undergo a Functional magnetic resonance imaging (fMRI) scan while performing a fear conditioning/extinction task at CSI-EUH and then either stay at CSI-EUH or relocate to the Neural Plasticity Research Laboratory at Emory Rehabilitation Hospital. Participants will then be randomly assigned to either receive active or sham continuous theta burst stimulation (cTBS) to transiently disrupt neural activity in the targeted sensory cortex region specifically during the sensory memory consolidation window.
Related Therapeutic Areas
Sponsors
Leads: Emory University

This content was sourced from clinicaltrials.gov

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