Post-Traumatic Stress Disorder (PTSD) Clinical Trials

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A Randomized Clinical Trial of Acceptance and Mindfulness-based Exposure Therapy (AMBET) and Present Centered Therapy (PCT)

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to learn if a new therapy called Acceptance- and Mindfulness-Based Exposure Therapy (AMBET) helps treat post-traumatic stress disorder (PTSD) in people who survived a cardiac arrest. This study will compare AMBET to another psychotherapy treatment called Present Centered Therapy (PCT) to see which therapy is more effective in treating PTSD. The main questions it aims to answer are: Does AMBET reduce PTSD symptoms in survivors of cardiac arrest? How do the benefits of AMBET compare to PCT? Participants will: * Be randomly assigned to receive either AMBET or PCT * Attend 12 hours of individual psychotherapy sessions over about 12 weeks * Complete short weekly surveys about their mood and behaviors online * Wear a Fitbit device to track sleep and activity during the study * Do brief homework assignments between sessions

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 81
Healthy Volunteers: f
View:

• Between 18 and 81 years old at the time of consent

• Fluency in English

• Medical history of cardiac arrest \>3 months ago

• Clinically elevated PTSD symptoms (Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) score ≥25)

• U.S. Resident

Locations
United States
New York
Columbia University Irving Medical Center
RECRUITING
New York
Contact Information
Primary
Yuval Neria, Ph.D.
ny126@cumc.columbia.edu
212-543-6061
Backup
Maja Bergman, Ph.D.
mb3829@cumc.columbia.edu
212-543-6061
Time Frame
Start Date: 2026-03-31
Estimated Completion Date: 2029-03-31
Participants
Target number of participants: 90
Treatments
Experimental: Acceptance- and mindfulness-based exposure therapy (AMBET)
Remotely delivered psychotherapy combining exposure therapy with mindfulness.
Active_comparator: Present-Centered Therapy (PCT)
Remotely delivered psychotherapy that focuses on increasing adaptive responses to current life stressors and difficulties.
Sponsors
Leads: Columbia University
Collaborators: National Institute on Aging (NIA)

This content was sourced from clinicaltrials.gov