Efficacy and Safety of Tamsulosin, a Selective Alpha-1 Adrenergic Blocker, for Children with Posterior Urethral Valve: a Randomized Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
To determine whether there is a role for Tamsulosin, A Selective Alpha-1 Adrenergic Blocker, as therapy in children with Posterior Urethral Valve post valve ablation , and whether there are side effects involved.
Eligibility
Participation Requirements
Sex: Male
Maximum Age: 12
Healthy Volunteers: f
View:
• Children with a diagnosis of PUV.
Locations
Other Locations
Egypt
Mansoura Urology and Nephrology Center
RECRUITING
Al Mansurah
Contact Information
Primary
Mohamed Hussiny
mohamedhussiny1@yahoo.com
+201064156383
Time Frame
Start Date: 2024-11-01
Estimated Completion Date: 2026-11
Participants
Target number of participants: 50
Treatments
Active_comparator: Oxybutynin and Trimethoprim/sulphamethoxazole
Patients will undergo maintenance therapy Anticholinergic, oxybutynin and Continous Antibiotic Prophylaxis,Trimethoprim/sulphamethoxazole daily
Experimental: Tamsulosin, Oxybutynin and Trimethoprim/sulfamethoxazole
Patients will undergo maintenance therapy Tamsulosin in addition to Anticholinergic, Oxybutynin and Continous Antibiotic Prophylaxis, Trimethoprim/sulfamethoxazole daily
Related Therapeutic Areas
Sponsors
Leads: Mansoura University