Study of Microvesicles in Pre-eclampsia
A large number of studies on MVs from syncytiotrophoblasts support the hypothesis of their involvement in pre-eclampsia, via their multiple effects, among others as pro-coagulant, immuno-stimulatory and anti-angiogenic factors. The main objective is to compare the total concentration of the main populations of MVs in the maternal blood of a population of pre-eclamptic patients to those of a population of non-pre-eclamptic patients.
• Age ≥ 18 years
• Singleton pregnancy (or spontaneously reduced twin pregnancy before 14 SA)
• Gestational age at inclusion between 23 and 31+6 SA
• Collection of the patient's non-opposition
• Affiliated or beneficiary of a social security system
• Specifically for the non-pre-eclampsia group: non-pre-eclamptic patient hospitalized for isolated threat of preterm delivery, whatever the origin, and without clinical (absence of maternal hyperthermia defined by a maternal temperature \< 38.0°C) or biological markers of inflammation (CRP\<5)
• Specifically for the pre-eclampsia group : diagnosis of severe pre-eclampsia before 32 weeks' gestation