Systematic Evaluation of Endothelial Dysfunction as a Prognostic Marker for Outcomes in Women With Preeclampsia

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

Preeclampsia is a pregnancy-specific hypertensive disorder and can progress rapidly to severe adverse outcomes affecting both the mother and the fetus. Endothelial and microcirculatory dysfunction mediate systemic preeclampsia-related organ dysfunctions. Changes in endothelial and vascular function in preeclampsia have been demonstrated through reduced flow-mediated vasodilation as a result of reduced availability of nitric oxide, which potentially persists up to several years postpartum. Hyperspectral imaging is a new innovative technology that allows to assess the peripheral microcirculation and perfusion non-invasively and contactless, but has never been evaluated in the context of preeclampsia before. This EPICS project (Endothelial dysfunction for Prognosis In patients with preeClampSia) is a prospective observational study and aims to investigate hyperspectral imaging as a new potential diagnostic and prognostic marker in preeclampsia.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: t
View:

• singleton pregnancies

• Age ≥ 18 years

• Patient's ability to provide consent

• written informed consent

Locations
Other Locations
Germany
Heidelberg University Hospital, Department of Gynecology and Obstetrics
RECRUITING
Heidelberg
Contact Information
Primary
Dr. med. Anna Scholz
anna.scholz@med.uni-heidelberg.de
+49 6221 56 32080
Time Frame
Start Date: 2025-05-08
Estimated Completion Date: 2027-07
Participants
Target number of participants: 385
Treatments
Preeclampsia
patients with diagnosis of preeclampsia according to definitions by the International Society for the Study of Hypertension in Pregnancy (n=110)
Pregnancy induced Hypertension and chronic Hypertension
patients with hypertension in pregnancy without fulfilling criteria of preeclampsia (n=110)
Normotensive pregnant control group
normotensive pregnancies (n=110)
Non-pregnant control group
normotensive, non-pregnant women (n=55)
Related Therapeutic Areas
Sponsors
Leads: Heidelberg University

This content was sourced from clinicaltrials.gov