Immunomodulation During Pregnancy Through Low-Dose Aspirin: a Hypothetical Mechanism for the Prevention of Preeclampsia?

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The goal of this observational study is to learn about the effects of low dose aspirin in immunity Pregnant women taking aspirin for other reasons (preeclampsia prevention) will be studied. The main question it aims to answer is: evaluate the effect of LDA on the modulation of innate immunity cells (NK cells, monocytes, γδ T cells) and/or acquired immunity (B and T lymphocytes, Treg cells, Th cells). Participants already taking intervention A as part of their regular medical care for RA will answer online survey questions about their joint pain for 5 years.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: t
View:

• Patients attending prenatal consultations at the Obstetrics Service A of CHUC, with the first consultation occurring before 14 weeks of gestation

• Gestational age determined by first-trimester ultrasound

• Study group: Women classified as high risk for PE according to clinical/historical criteria and the Fetal Medicine Foundation algorithm. LDA-naïve.

Locations
Other Locations
Portugal
Unidade Local de Saúde de Coimbra, E.P.E.
RECRUITING
Coimbra
Contact Information
Primary
Ana L Areia, PhD, MD
analuisareia@gmail.com
+351917212222
Backup
João Sargento-Freitas, PhD
joaosargentofreitas@ulscoimbra.min-saude.pt
+351239400488
Time Frame
Start Date: 2024-02-01
Estimated Completion Date: 2025-03-31
Participants
Target number of participants: 30
Treatments
Healthy pregnancies
High-risk preeclampsia pregnencies
Related Therapeutic Areas
Sponsors
Leads: Unidade Local de Saúde de Coimbra, EPE

This content was sourced from clinicaltrials.gov