Long Term Management of Peripheral Avascular Retina in Retinopathy of Prematurity Evaluated by Fundus Fluorescein Angiography.

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Retinopathy of prematurity (ROP) is a widely known retinal vascular disorder in preterm infants and a leading cause of visual disability or blindness in children. Advances in antenatal care have resulted in an increase in the survival rate of infants with extremely low birth weight (BW). Approximately 90% of infants who develop ROP do so by a postmenstrual age of 46.3 weeks. In certain patients with or without treatment, the retina may fail to fully vascularize or may develop vascular abnormalities, thus demonstrating persistent avascular retina (PAR) or anomalous vessel findings at the periphery. Because of the advent of technologies such as ultrawide-field fluorescein angiography (UWFFA) persistent vascular abnormalities can be detected more readily and investigated.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 1
Maximum Age: 3
Healthy Volunteers: f
View:

• Patients with persistent peripheral avascular retina attending follow up till the age of 18 months in the core study whether;

• regressed ROP: children with regressed ROP who had not received any treatment.

• IVI treatment ROP: children with a history of threshold ROP treated with IVI of anti-VEGF agents.

Locations
Other Locations
Egypt
Assiut University Hospital
RECRUITING
Asyut
Contact Information
Primary
Alyaa Mohamed, MS
alyaelkabsh686@gmail.com
01092246445
Time Frame
Start Date: 2024-01-01
Estimated Completion Date: 2025-11-01
Participants
Target number of participants: 32
Treatments
No_intervention: Peripheral avascular retina of ROP with no leakage.
If there is no active leakage detected by FFA, patients would be observed. The follow-up period: FFA will be done at the age of 18 months we will repeat FFA every 6 months and fundus examination with color photography every 3 months till the age of 3 years of children.
Active_comparator: Peripheral avascular retina of ROP with active leakage.
If there is evidence of active leakage by FFA The confluent laser burns will be applied to the entire avascular retina from the ridge to the ora serrata for 360 through the transpupillary route.
Sponsors
Leads: Assiut University

This content was sourced from clinicaltrials.gov