Condition 101 About Retinopathy of Prematurity

What is the definition of Retinopathy of Prematurity?

Retinopathy of prematurity (ROP) is abnormal blood vessel development in the retina of the eye. It occurs in infants that are born too early (premature).

What are the alternative names for Retinopathy of Prematurity?

Retrolental fibroplasia; ROP

What are the causes for Retinopathy of Prematurity?

The blood vessels of the retina (in the back of the eye) begin to develop about 3 months into pregnancy. In most cases, they are fully developed at the time of normal birth. The eyes may not develop properly if a baby is born very early. The vessels may stop growing or grow abnormally from the retina into the back of the eye. Because the vessels are fragile, they can leak and cause bleeding in the eye.

Scar tissue may develop and pull the retina loose from the inner surface of the eye (retinal detachment). In severe cases, this can result in vision loss.

In the past, the use of too much oxygen in treating premature babies caused vessels to grow abnormally. Better methods are now available for monitoring oxygen. As a result, the problem has become less common, especially in developed countries. However, there is still uncertainty about the right level of oxygen for premature babies at different ages. Researchers are studying other factors besides oxygen which appear to influence the risk of ROP.

Today, the risk of developing ROP depends on the degree of prematurity. Smaller babies with more medical problems are at higher risk.

Almost all babies who are born before 30 weeks or weigh less than 3 pounds (1500 grams or 1.5 kilograms) at birth are screened for the condition. Some high-risk babies who weigh 3 to 4.5 pounds (1.5 to 2 kilograms) or who are born after 30 weeks should also be screened.

In addition to prematurity, other risk factors may include:

  • Brief stop in breathing (apnea)
  • Heart disease
  • High carbon dioxide (CO2) in the blood
  • Infection
  • Low blood acidity (pH)
  • Low blood oxygen
  • Respiratory distress
  • Slow heart rate (bradycardia)
  • Transfusions

The rate of ROP in most premature infants has gone down greatly in developed countries over the past few decades due to better care in the neonatal intensive care unit (NICU). However, more babies born very early are now able to survive, and these very premature infants are at the highest risk for ROP.

What are the symptoms for Retinopathy of Prematurity?

The blood vessel changes cannot be seen with the naked eye. An eye exam by an ophthalmologist is needed to reveal such problems.

There are five stages of ROP:

  • Stage I: There is mildly abnormal blood vessel growth.
  • Stage II: Blood vessel growth is moderately abnormal.
  • Stage III: Blood vessel growth is severely abnormal.
  • Stage IV: Blood vessel growth is severely abnormal and there is a partially detached retina.
  • Stage V: There is a total retinal detachment.

An infant with ROP may also be classified as having "plus disease" if the abnormal blood vessels match pictures used to diagnose the condition.

Symptoms of severe ROP include:

  • Abnormal eye movements
  • Crossed eyes
  • Severe nearsightedness
  • White-looking pupils (leukocoria)

What are the current treatments for Retinopathy of Prematurity?

Early treatment has been shown to improve a baby's chances for normal vision. Treatment should start within 72 hours of the eye exam.

Some babies with "plus disease" need immediate treatment.

  • Laser therapy (photocoagulation) may be used to prevent complications of advanced ROP.
  • The laser stops the abnormal blood vessels from growing.
  • The treatment can be done in the nursery using portable equipment. To work well, it must be done before the retina develops scarring or detaches from the rest of the eye.
  • Other treatments, such as injecting an antibody that blocks VEG-F (a blood vessel growth factor) into the eye, are still being studied.

Surgery is needed if the retina detaches. Surgery does not always result in good vision.

What is the outlook (prognosis) for Retinopathy of Prematurity?

Most infants with severe vision loss related to ROP have other problems related to early birth. They will need many different treatments.

About 1 out of 10 infants with early changes will develop more severe retinal disease. Severe ROP may lead to major vision problems or blindness. The key factor in the outcome is early detection and treatment.

What are the possible complications for Retinopathy of Prematurity?

Complications may include severe nearsightedness or blindness.

How do I prevent Retinopathy of Prematurity?

The best way to prevent this condition is to take steps to avoid premature birth. Preventing other problems of prematurity may also help prevent ROP.

REFERENCES

Fierson WM; American Academy of Pediatrics Section on Ophthalmology; American Academy of Ophthalmology; American Association for Pediatric Ophthalmology and Strabismus; American Association of Certified Orthoptists. Screening examination of premature infants for retinopathy of prematurity. Pediatrics. 2018;142(6):e20183061. Pediatrics. 2019;143(3):2018-3810. PMID: 30824604 www.ncbi.nlm.nih.gov/pubmed/30824604.

Olitsky SE, Marsh JD. Disorders of the retina and vitreous. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 648.

Sun Y, Hellström A, Smith LEH. Retinopathy of prematurity. In: Martin RJ, Fanaroff AA, Walsh MC, eds. Fanaroff and Martin's Neonatal-Perinatal Medicine. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 96.

Thanos A, Drenser KA, Capone AC. Retinopathy of prematurity. In: Yanoff M, Duker JS, eds. Ophthalmology. 5th ed. Philadelphia, PA: Elsevier; 2019:chap 6.21.

Latest Advances On Retinopathy of Prematurity

  • Condition: Preterm Infancy
  • Journal: The Cochrane database of systematic reviews
  • Treatment Used: Individualized or Standard Diet Fortification
  • Number of Patients: 521
  • Published —
This study compared the clinical outcome of using an individualized or standard diet fortification on preterm infants to improve their growth and development.
  • Condition: Very Preterm Infants at Risk of Developing Retinopathy of Prematurity (ROP)
  • Journal: Journal of translational medicine
  • Treatment Used: Recombinant Human Erythropoietin (rhEPO)
  • Number of Patients: 1898
  • Published —
This study evaluated the effect of early prophylactic low-dose recombinant human erythropoietin (hormone that stimulates the process of red blood cell production; rhEPO) in very preterm infants at risk of developing retinopathy of prematurity (disease of the eye affecting prematurely born babies; ROP).

Clinical Trials For Retinopathy of Prematurity

Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 2
  • Intervention Type: Drug
  • Participants: 276
  • Start Date: June 15, 2021
Oral Propranolol for Prevention of Threshold Retinopathy of Prematurity
Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 2
  • Intervention Type: Drug
  • Participants: 80
  • Start Date: April 2021
Bevacizumab Treatment For Posterior Zone I Retinopathy of Prematurity