Crossover Study of the Cerebral Blood Flow and Cardiac Output At Different Targeted Tidal Volumes During High Frequency Oscillation with Volume Targeted Ventilation (HFO&VTV)

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Mechanical ventilation (MV) is life saving for infants requiring respiratory support in the newborn period but its use has been associated with complications. High frequency oscillation (HFO) is a type of MV that delivers small volumes of gas across the lungs at fast frequencies. HFO is a lung protective strategy but it has also been linked to brain injury due to low carbon dioxide tensions. High-frequency oscillation with volume-targeted ventilation (HFO\&VTV) is a new mode of HFO in which the clinician sets a target volume of gas to be delivered to the lungs at fast rates to decrease the lung injury related to the ventilator. Further, HFO\&VTV achieves better control of carbon dioxide levels and may therefore protect against brain injury. Currently, there are no written guidelines about the use of HFO\&VTV. This study aim to determine the safety profile of HFO\&VTV compared to HFO by comparing the velocity of blood flow to the brain in term born infants and the cardiac output in term and preterm infants during the two modes. The investigators will also determine the optimum starting value of the target tidal volume during HFOV\&VTV. Infants will be studied at three different target tidal volumes for a period of 10-20 minutes each. A cranial ultrasound (for term infants only) and bedside echocardiogram will be performed at the end of each period.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 5 months
Maximum Age: 1
Healthy Volunteers: f
View:

• Newborn infants of any gestation receiving high frequency oscillatory ventilation

Locations
Other Locations
United Kingdom
King's College Hospital
RECRUITING
London
Contact Information
Primary
Ourania Kaltsogianni, MSc
ourania.kaltsogianni@nhs.net
0044+02032999000
Backup
Theodore Dassios
theodore.dassios@nhs.net
Time Frame
Start Date: 2025-02-26
Estimated Completion Date: 2026-09-01
Participants
Target number of participants: 27
Treatments
Active_comparator: High frequency oscillation at the settings applied prior to the study
Active_comparator: High frequency oscillation with volume targeted ventilation
Related Therapeutic Areas
Sponsors
Leads: King's College Hospital NHS Trust

This content was sourced from clinicaltrials.gov