Learn About Premature Ovarian Failure

What is the definition of Premature Ovarian Failure?

Premature ovarian failure is reduced function of the ovaries (including decreased production of hormones). Ovarian failure that occurs before the age of 40 is considered premature ovarian failure.

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What are the alternative names for Premature Ovarian Failure?

Ovarian hypofunction; Ovarian insufficiency

What are the causes of Premature Ovarian Failure?

Premature ovarian failure may be caused by genetic factors such as chromosome abnormalities. It may also occur with certain autoimmune disorders that disrupt the normal function of the ovaries. Most often there is no obvious cause, although a family history of the condition may play a role.

Chemotherapy and radiation therapy can also cause premature ovarian failure.

What are the symptoms of Premature Ovarian Failure?

Women with premature ovarian failure may develop symptoms of menopause, which include:

  • Hot flashes
  • Irregular or absent periods
  • Mood swings
  • Night sweats
  • Vaginal dryness

This condition may also make it hard for a woman to become pregnant.

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What are the current treatments for Premature Ovarian Failure?

Estrogen therapy often helps relieve menopausal symptoms and prevents bone loss. However, it will not increase your chances of becoming pregnant. Fewer than 1 in 10 women with this condition will be able to get pregnant. The chance of getting pregnant increases to 50% when you use a fertilized donor egg (an egg from another woman).

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When should I contact a medical professional for Premature Ovarian Failure?

Call your health care provider if:

  • You are no longer having monthly periods.
  • You have symptoms of early menopause.
  • You are having difficulty becoming pregnant.
Ovarian hypofunction
What are the latest Premature Ovarian Failure Clinical Trials?
The Safety and Efficacy Assessment of Human Amniotic Mesenchymal Stem Cells(hAMSCs) Transplantation in Woman With Diminished Ovarian Reserve (DOR)

Summary: Patients with Diminished ovarian response (DOR)have a poor in vitro fertilization(IVF) outcome, and is considered one of most challenging tasks in artificial reproductive treatment (ART). Stem cell therapies are rapidly progressing fields and have shown promise in treatment of lots of disease, including aging and premature ovarian failure. The purpose of this study is to determine the safety and e...

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Clinical Efficacy Analysis of Resveratrol in the Treatment of Primary Ovarian Insufficiency

Summary: Resveratrol is a natural plant antitoxin widely found in grapes, mulberries, and other plants. Resveratrol mediates a variety of pharmacological effects, including antioxidant, immunomodulatory, anti-inflammatory, and anti-apoptotic, and plays a protective and therapeutic role in the development of several ROS-related diseases, including POI/POF.

What are the Latest Advances for Premature Ovarian Failure?
Hormone therapy for uterine and endometrial development in women with premature ovarian insufficiency.
Hormone therapy in women with premature ovarian insufficiency: a systematic review and meta-analysis.
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Case report: Birth achieved after effective ovarian stimulation combined with dexamethasone in a patient with resistant ovary syndrome.
Who are the sources who wrote this article ?

Published Date: April 19, 2022
Published By: John D. Jacobson, MD, Department of Obstetrics and Gynecology, Loma Linda University School of Medicine, Loma Linda, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Broekmans FJ, Fauser BCJM. Female infertility: evaluation and management. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 132.

Bulun SE. Physiology and pathology of the female reproductive axis. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 17.

Douglas NC, Lobo RA. Reproductive endocrinology: neuroendocrinology, gonadotropins, sex steroids, prostaglandins, ovulation, menstruation, and hormone assay. In: Lobo RA, Gershenson DM, Lentz GM, Valea FA, Lobo RA, eds. Comprehensive Gynecology. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 4.

Dumesic DA, Gambone JC. Amenorrhea, oligomenorrhea, and hyperandrogenic disorders. In: Hacker NF, Gambone JC, Hobel CJ, eds. Hacker & Moore's Essentials of Obstetrics and Gynecology. 6th ed. Philadelphia, PA: Elsevier; 2016:chap 33.

Lobo RA. Menopause and aging. In: Strauss JF, Barbieri RL, eds. Yen and Jaffe's Reproductive Endocrinology. 8th ed. Philadelphia, PA: Elsevier; 2019:chap 14.