What is the definition of Premature Ovarian Failure?

Premature ovarian failure is reduced function of the ovaries (including decreased production of hormones).

What are the alternative names for Premature Ovarian Failure?

Ovarian hypofunction; Ovarian insufficiency

What are the causes for Premature Ovarian Failure?

Premature ovarian failure may be caused by genetic factors such as chromosome abnormalities. It may also occur with certain autoimmune disorders that disrupt the normal function of the ovaries.

Chemotherapy and radiation therapy can also cause the condition to occur.

What are the symptoms for Premature Ovarian Failure?

Women with premature ovarian failure may develop symptoms of menopause, which include:

  • Hot flashes
  • Irregular or absent periods
  • Mood swings
  • Night sweats
  • Vaginal dryness

This condition may also make it hard for a woman to become pregnant.

What are the current treatments for Premature Ovarian Failure?

Estrogen therapy often helps relieve menopausal symptoms and prevents bone loss. However, it will not increase your chances of becoming pregnant. Fewer than 1 in 10 women with this condition will be able to get pregnant. The chance of getting pregnant increases to 50% when you use a fertilized donor egg (an egg from another woman).

When should I contact a medical professional for Premature Ovarian Failure?

Call your health care provider if:

  • You are no longer having monthly periods.
  • You have symptoms of early menopause.
  • You are having difficulty becoming pregnant.
Ovarian hypofunction


Broekmans FJ, Fauser BCJM. Female infertility: evaluation and management. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 132.

Bulun SE. Physiology and pathology of the female reproductive axis. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 17.

Douglas NC, Lobo RA. Reproductive endocrinology: neuroendocrinology, gonadotropins, sex steroids, prostaglandins, ovulation, menstruation, hormone assay. In: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. Comprehensive Gynecology. 7th ed. Philadelphia, PA: Elsevier; 2017:chap 4.

Dumesic DA, Gambone JC. Amenorrhea, oligomenorrhea, and hyperandrogenic disorders. In: Hacker NF, Gambone JC, Hobel CJ, eds. Hacker & Moore's Essentials of Obstetrics and Gynecology. 6th ed. Philadelphia, PA: Elsevier; 2016:chap 33.

Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 4
  • Intervention Type: Drug
  • Participants: 120
  • Start Date: September 1, 2021
A Multi-center Clinical Study on the Efficacy and Safety of Kuntai Capsule Alone and in Combination With Hormones in the Treatment of Early-onset Hypoovarian Function
Clinical Trial
  • Status: Enrolling by invitation
  • Phase: Phase 1/Phase 2
  • Intervention Type: Combination Product
  • Participants: 100
  • Start Date: June 1, 2019
Platelet Rich Plasma Ovarian in Vitro Activation and Stem Cells Transplantation In Women With Ovarian Failure