Primary Amebic MeningoencephalitisSymptoms, Doctors, Treatments, Advances & More
Primary Amebic Meningoencephalitis Overview
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Montefiore Weiler Hospital
Our primary research interest is in the biology, pathogenesis and immunology of Plasmodium falciparum. Patients infected with this parasite can be completely asymptomatic or develop severe disease resulting in death. The goal of our research has been to define the molecular mechanisms that underlie this variation in disease outcomes in P. falciparum. Toward this goal, we have developed a new pathogenesis model through the analysis of in vivo parasite biology and associated host factors using a whole genome and metabolomic approach. We have identified novel parasite biology when it resides in the human host and idnetified a putative mediator of coma in cerebral malaria. We also are studying adjunctive therapy to improve outcomes in severe malaria using the animal model. We carry out field based translational studies in cohorts infected with malaria in Africa and test hypothesis in the animal model of malaria. The long term goal is to identify parasite and host processes involved in disease to serve as targets for vaccine or chemotherapeutic development. Dr. Daily is rated as an Elite provider by MediFind in the treatment of Primary Amebic Meningoencephalitis. Her top areas of expertise are Primary Amebic Meningoencephalitis, Malaria, Togaviridae Disease, Severe Acute Respiratory Syndrome (SARS), and Leg or Foot Amputation.
University Of Rochester
Michael Potchen is a Neuroradiologist in Rochester, New York. Dr. Potchen is rated as an Elite provider by MediFind in the treatment of Primary Amebic Meningoencephalitis. His top areas of expertise are Primary Amebic Meningoencephalitis, CACH Syndrome, Headache, and Brain Herniation.
Emory University Hospital Midtown
Jennifer Cope is an Anesthesiologist in Atlanta, Georgia. Dr. Cope has been practicing medicine for over 12 years and is rated as an Elite provider by MediFind in the treatment of Primary Amebic Meningoencephalitis. Her top areas of expertise are Primary Amebic Meningoencephalitis, Amebiasis, Meningitis, and Long Haul COVID.
Summary: Toxoplasmosis in HIV-positive individuals is well-studied and has a codified management protocol, which is not the case for other immunodeficiencies, except for recent recommendations in the context of hematopoietic stem cell transplantation. A description of this population is necessary to estimate the number of patients affected and to define their specific management (diagnosis, treatment, prev...
Summary: The goal of this clinical trial is to evaluate the safety of a single intravenous dose of DON in healthy adults, adults with uncomplicated malaria, and children 12 months-14 years old with clinically defined Cerebral Malaria. The main objectives are: * Determine the pharmacokinetic (PK) profile of a single dose of DON in children with CM * Determine if administration of a single intravenous dose o...
