Primary Amebic Meningoencephalitis
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Learn About Primary Amebic Meningoencephalitis

What is the definition of Primary Amebic Meningoencephalitis?
Primary amoebic meningoencephalitis (PAM) is a rare, usually fatal brain infection caused by the single-celled living organism (amoeba), Naegleria fowleri, which is commonly found in warm freshwater environments, such as rivers, lakes, hot springs, swimming pools, contaminated drinking water, water heaters, and soil. Naegleria fowleri is also popularly known as the “brain-eating amoeba.” This amoeba infects humans through the nose, and then travels to the brain wherein it causes primary amoebic meningoencephalitis (inflammation of the brain and the tissues that surround it and the spinal cord ).
What are the symptoms of Primary Amebic Meningoencephalitis?
Symptoms of primary amoebic meningoencephalitis occur within 1 to 9 days after infection and can be similar to bacterial meningitis. Early symptoms may include fever, headache, nausea and vomiting. Later symptoms may include stiff neck, mental confusion, hallucinations, loss of balance, and seizures. Primary amoebic meningoencephalitis is usually fatal within 3 to 7 days.
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What are the current treatments for Primary Amebic Meningoencephalitis?
Treatment for primary amoebic meningoencephalitis is still mostly undefined, as most all individuals infected with Naegleria fowleri have died within days. However, two patients recently infected Naegleria fowleri survived after treatment with the drug, miltefosine, which was administered in combination with other drugs and treatments for the brain swelling associated with primary amoebic meningoencephalitis.
Who are the top Primary Amebic Meningoencephalitis Local Doctors?
Johanna P. Daily
Elite in Primary Amebic Meningoencephalitis
Infectious Disease
Elite in Primary Amebic Meningoencephalitis
Infectious Disease

Montefiore Weiler Hospital

1825 Eastchester Road, 
Bronx, NY 
Languages Spoken:
English

Our primary research interest is in the biology, pathogenesis and immunology of Plasmodium falciparum. Patients infected with this parasite can be completely asymptomatic or develop severe disease resulting in death. The goal of our research has been to define the molecular mechanisms that underlie this variation in disease outcomes in P. falciparum. Toward this goal, we have developed a new pathogenesis model through the analysis of in vivo parasite biology and associated host factors using a whole genome and metabolomic approach. We have identified novel parasite biology when it resides in the human host and idnetified a putative mediator of coma in cerebral malaria.  We also are studying adjunctive therapy to improve outcomes in severe malaria using the animal model.   We carry out field based translational studies in cohorts infected with malaria in Africa and test hypothesis in the animal model of malaria.  The long term goal is to identify parasite and host processes involved in disease to serve as targets for vaccine or chemotherapeutic development. Dr. Daily is rated as an Elite provider by MediFind in the treatment of Primary Amebic Meningoencephalitis. Her top areas of expertise are Primary Amebic Meningoencephalitis, Malaria, Togaviridae Disease, Severe Acute Respiratory Syndrome (SARS), and Leg or Foot Amputation.

Elite in Primary Amebic Meningoencephalitis
Neuroradiology
Elite in Primary Amebic Meningoencephalitis
Neuroradiology

University Of Rochester

601 Elmwood Ave, 
Rochester, NY 
Languages Spoken:
English

Michael Potchen is a Neuroradiologist in Rochester, New York. Dr. Potchen is rated as an Elite provider by MediFind in the treatment of Primary Amebic Meningoencephalitis. His top areas of expertise are Primary Amebic Meningoencephalitis, CACH Syndrome, Headache, and Brain Herniation.

 
 
 
 
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Elite in Primary Amebic Meningoencephalitis
Anesthesiology
Elite in Primary Amebic Meningoencephalitis
Anesthesiology

Emory University Hospital Midtown

550 Peachtree Street Northeast, 
Atlanta, GA 
Experience:
12+ years
Languages Spoken:
English, Mandarin

Jennifer Cope is an Anesthesiologist in Atlanta, Georgia. Dr. Cope has been practicing medicine for over 12 years and is rated as an Elite provider by MediFind in the treatment of Primary Amebic Meningoencephalitis. Her top areas of expertise are Primary Amebic Meningoencephalitis, Amebiasis, Meningitis, and Long Haul COVID.

What are the latest Primary Amebic Meningoencephalitis Clinical Trials?
Retrospective Descriptive Study of a Cohort of Non-HIV Immunocompromised Patients With Toxoplasmosis at the Strasbourg University Hospital From 2010 to 2023

Summary: Toxoplasmosis in HIV-positive individuals is well-studied and has a codified management protocol, which is not the case for other immunodeficiencies, except for recent recommendations in the context of hematopoietic stem cell transplantation. A description of this population is necessary to estimate the number of patients affected and to define their specific management (diagnosis, treatment, prev...

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DON in Pediatric Cerebral Malaria: A Phase I/IIa Dose-Escalation Safety Study

Summary: The goal of this clinical trial is to evaluate the safety of a single intravenous dose of DON in healthy adults, adults with uncomplicated malaria, and children 12 months-14 years old with clinically defined Cerebral Malaria. The main objectives are: * Determine the pharmacokinetic (PK) profile of a single dose of DON in children with CM * Determine if administration of a single intravenous dose o...