Haemodynamic Effects of Dobutamine in Patients With Wild-type Transthyretin Amyloid Cardiomyopathy (ATTRwt)

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 1/Phase 2
SUMMARY

The goal of this clinical trial is to test the effects of the inotropic drug named dobutamine, in patients with wild-type Transthyretin Amyoid Cardiomyopathy (ATTRwt). The main questions it aims to answer are: * What are the effects of increasing dosages of dobutamine infusion on cardiac output and filling pressures in patients with symptomatic ATTRwt. * Safety of dobutamine infusion in this patient population. Participants will be given increasing dosages of dobutamine infusion, and its effect on cardiac output and filling pressures will be assessed non-invasively by echocardiography, and invasively by right heart catheterization, simultaneously.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Healthy Volunteers: f
View:

• ATTRwt, diagnosis confirmed by genetic testing, 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scintigraphy and/or endomyocardial biopsy.

• Treated with loop diuretics.

• New York Heart Association class II-IV.

• Age ≥ 65 years.

• Left ventricular ejection fraction (LVEF) \< 50 % and/or SVI assessed by echocardiography \< 35 ml/m2.

• Thorough oral and written informed consent to participate in the study.

Locations
Other Locations
Denmark
Department of Cardiology, Aarhus University Hospital
RECRUITING
Aarhus
Contact Information
Primary
Ali Hussein Jaber Mejren, MD
alimej@clin.au.dk
0045 91 65 18 48
Backup
Steen Hvitfeldt Poulsen, MD,PhD,DMSci
steepoul@rm.dk
Time Frame
Start Date: 2024-04-08
Estimated Completion Date: 2026-03
Participants
Target number of participants: 35
Treatments
Experimental: ATTRwt
Dobutamine (Dobutrex®) infusion.
Sponsors
Leads: Steen Hvitfeldt Poulsen

This content was sourced from clinicaltrials.gov