Pathogenic Study of Adult Immune Enteropathies
Status: Recruiting
Location: See all (4) locations...
Intervention Type: Genetic
Study Type: Observational
SUMMARY
The study focuses the mechanisms underlying the loss of intestinal homeostasis in celiac disease, refractory celiac disease and other immune diseases such as monogenic enteropathy, inflammatory bowel diseases or drug induced intestinal diseases. Mechanisms of transformation of lymphocytes leading to onset of lymphomatous complications of immune enteropathies will be investigated. Mechanisms of loss of hepatic lymphocytic homeostasis will also be assessed in liver associated diseases.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• 18 years or over
• affiliated to social insurance
• signed informed consent
Locations
Other Locations
France
Hôpital Henri Mondor
NOT_YET_RECRUITING
Créteil
Hôpital Bicêtre
NOT_YET_RECRUITING
Le Kremlin-bicêtre
Hôpital Cochin
RECRUITING
Paris
Hôpital Saint Louis
NOT_YET_RECRUITING
Paris
Contact Information
Primary
Georgia MALAMUT, MD, PhD
georgia.malamut@aphp.fr
33 1 58 41 41 76
Backup
Anaïs LEVESCOT, MD, PhD
anais.levescot@inserm.fr
33 1 42 75 42 77
Time Frame
Start Date: 2020-02-27
Estimated Completion Date: 2033-02-27
Participants
Target number of participants: 200
Treatments
Active coeliac patients
Patients with active coeliac disease
Treated coeliac patients
Patients with coeliac disease on gluten free diet
Sprue type I
Patients with refractory coeliac disease of type I
Sprue type II
Patients with refractory coeliac disease of type II
Intestinal Lymphoproliferations
Patients with intestinal lymphoproliferations
Non coeliac enteropathies
Patients with non coeliac immune-mediated enteropathy
Patients without neoplastic or inflammatory intestinal disease
Patients without neoplastic or inflammatory intestinal disease
Authors
Related Therapeutic Areas
Sponsors
Leads: Institut National de la Santé Et de la Recherche Médicale, France
Collaborators: Imagine Institute