Learn About Primary Localized Cutaneous Amyloidosis

What is the definition of Primary Localized Cutaneous Amyloidosis?

Primary localized cutaneous amyloidosis (PLCA) is a condition in which clumps of abnormal proteins called amyloids build up in the skin, specifically in the wave-like projections (dermal papillae) between the top two layers of skin (the dermis and the epidermis). The primary feature of PLCA is patches of skin with abnormal texture or color. The appearance of these patches defines three forms of the condition: lichen amyloidosis, macular amyloidosis, and nodular amyloidosis.

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What are the causes of Primary Localized Cutaneous Amyloidosis?

PLCA can be caused by mutations in the OSMR or IL31RA gene. When caused by an OSMR gene mutation, the condition is classified as type 1, while an IL31RA gene mutation causes type 2. Mutations in either gene are likely involved in lichen and macular amyloidosis, which are thought to be related conditions that arise through similar disease mechanisms. The genetic basis of nodular amyloidosis is unknown.

How prevalent is Primary Localized Cutaneous Amyloidosis?

PLCA occurs worldwide, most commonly in Southeast Asia and South America. The prevalence of the condition is unknown.

Is Primary Localized Cutaneous Amyloidosis an inherited disorder?

In most cases, PLCA is not inherited and occurs in people with no history of the condition in their family.

Who are the top Primary Localized Cutaneous Amyloidosis Local Doctors?
Elite
Highly rated in
6
conditions

University Of Regensburg

Franz Josef Strauß Allee 11 
Regensburg, BY, DE 93053

Stephan Schreml is in Regensburg, Germany. Schreml is rated as an Elite expert by MediFind in the treatment of Primary Localized Cutaneous Amyloidosis. He is also highly rated in 6 other conditions, according to our data. His top areas of expertise are Primary Localized Cutaneous Amyloidosis, Multiple Symmetric Lipomatosis, Familial Multiple Lipomatosis, and Pyoderma Gangrenosum.

Elite
Highly rated in
15
conditions

National Skin Centre

Singapore, SG 11754

Hong Tey is in Singapore, Singapore. Tey is rated as an Elite expert by MediFind in the treatment of Primary Localized Cutaneous Amyloidosis. She is also highly rated in 15 other conditions, according to our data. Her top areas of expertise are Primary Localized Cutaneous Amyloidosis, Anhidrosis, Notalgia Paresthetica, and Acrospiroma.

 
 
 
 
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Distinguished
Highly rated in
20
conditions
Cardiology

VCU Health

VCU Medical Center Main Hospital

1250 E Marshall St 
Richmond, VA 23298

Keyur Shah is a Cardiologist in Richmond, Virginia. Dr. Shah has been practicing medicine for over 19 years and is rated as a Distinguished doctor by MediFind in the treatment of Primary Localized Cutaneous Amyloidosis. He is also highly rated in 20 other conditions, according to our data. His top areas of expertise are Heart Failure, Cardiac Amyloidosis, Cardiomyopathy, and Transthyretin Amyloidosis. He is board certified in Advanced Heart Failure And Transplant Cardiology, Cardiovascular Disease (Cardiology), and Internal Medicine and licensed to treat patients in Virginia. Dr. Shah is currently accepting new patients.

What are the latest Primary Localized Cutaneous Amyloidosis Clinical Trials?
Use of [F-18] FLT for Imaging With Positron Emission Tomography (PET)
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Carolina Senior: UNC Registry for Older Cancer Patients
Who are the sources who wrote this article ?

Published Date:updated Last, March

Published By: National Institutes of Health

What are the Latest Advances for Primary Localized Cutaneous Amyloidosis?
Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study.
Clinical resolution of generalized lichen amyloidosis with dupilumab: a new alternative therapy.
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