Learn About Primary Localized Cutaneous Amyloidosis

What is the definition of Primary Localized Cutaneous Amyloidosis?

Primary localized cutaneous amyloidosis (PLCA) is a condition in which clumps of abnormal proteins called amyloids build up in the skin, specifically in the wave-like projections (dermal papillae) between the top two layers of skin (the dermis and the epidermis). The primary feature of PLCA is patches of skin with abnormal texture or color. The appearance of these patches defines three forms of the condition: lichen amyloidosis, macular amyloidosis, and nodular amyloidosis.

Save information for later
Sign Up
What are the causes of Primary Localized Cutaneous Amyloidosis?

PLCA can be caused by mutations in the OSMR or IL31RA gene. When caused by an OSMR gene mutation, the condition is classified as type 1, while an IL31RA gene mutation causes type 2. Mutations in either gene are likely involved in lichen and macular amyloidosis, which are thought to be related conditions that arise through similar disease mechanisms. The genetic basis of nodular amyloidosis is unknown.

How prevalent is Primary Localized Cutaneous Amyloidosis?

PLCA occurs worldwide, most commonly in Southeast Asia and South America. The prevalence of the condition is unknown.

Is Primary Localized Cutaneous Amyloidosis an inherited disorder?

In most cases, PLCA is not inherited and occurs in people with no history of the condition in their family.

Who are the top Primary Localized Cutaneous Amyloidosis Local Doctors?
Learn about our expert tiers
Learn more
What are the latest Primary Localized Cutaneous Amyloidosis Clinical Trials?
Natural History of Severe Allergic Inflammation and Reactions

Background: - Allergic inflammation is central to allergy-related diseases and disorders, such as asthma, food allergies, and atopic dermatitis. Atopic dermatitis, commonly called eczema is a chronic, noncontagious skin condition, usually starting in the first years of life, which causes itching and scaling of an individual s skin. Because atopic dermatitis is a common condition in children who have allergy-r...

Match to trials
Find the right clinical trials for you in under a minute
Get started
Who are the sources who wrote this article ?

Published Date: March 01, 2017Published By: National Institutes of Health

What are the Latest Advances for Primary Localized Cutaneous Amyloidosis?
Clinical resolution of generalized lichen amyloidosis with dupilumab: a new alternative therapy.
Tired of the same old research?
Check Latest Advances