Learn About Primary Lymphoma of the Brain

What is the definition of Primary Lymphoma of the Brain?

Primary lymphoma of the brain is cancer of white blood cells that starts in the brain.

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What are the alternative names for Primary Lymphoma of the Brain?

Brain lymphoma; Cerebral lymphoma; Primary lymphoma of the central nervous system; PCNSL; Lymphoma - B-cell lymphoma, brain

What are the causes of Primary Lymphoma of the Brain?

The cause of primary brain lymphoma is not known.

People with a weakened immune system are at high risk for primary lymphoma of the brain. Common causes of a weakened immune system include HIV/AIDS and having had an organ transplant (especially heart transplant).

Primary lymphoma of the brain may be linked to Epstein-Barr Virus (EBV), especially in people with HIV/AIDS. EBV is the virus that causes mononucleosis.

Primary brain lymphoma is more common in people ages 45 to 70. The rate of primary brain lymphoma is rising. Almost 1,500 new patients are diagnosed with primary brain lymphoma every year in the United States.

What are the symptoms of Primary Lymphoma of the Brain?

Symptoms of primary brain lymphoma may include any of the following:

  • Changes in speech or vision
  • Confusion or hallucinations
  • Seizures
  • Headaches, nausea, or vomiting
  • Leaning to one side when walking
  • Weakness in hands or loss of coordination
  • Numbness to hot, cold, and pain
  • Personality changes
  • Weight loss
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What are the current treatments for Primary Lymphoma of the Brain?

Primary lymphoma of the brain is often first treated with corticosteroids. These medicines are used to control swelling and improve symptoms. The main treatment is with chemotherapy.

Younger people may receive high-dose chemotherapy, possibly followed by an autologous stem cell transplant.

Radiation therapy of the whole brain may be done after chemotherapy.

Boosting the immune system, such as in those with HIV/AIDS, may also be tried.

You and your health care provider may need to manage other concerns during your treatment, including:

  • Having chemotherapy at home
  • Managing your pets during chemotherapy
  • Bleeding problems
  • Dry mouth
  • Eating enough calories
  • Safe eating during cancer treatment
Who are the top Primary Lymphoma of the Brain Local Doctors?
Elite
Highly rated in
8
conditions
Oncology

Providence Health & Services

Hematology And Blood And Marrow Transplant

400 Parnassus Ave 
San Francisco, CA 94143

James Rubenstein is an Oncologist in San Francisco, California. Dr. Rubenstein has been practicing medicine for over 30 years and is rated as an Elite doctor by MediFind in the treatment of Primary Lymphoma of the Brain. He is also highly rated in 8 other conditions, according to our data. His top areas of expertise are Primary Lymphoma of the Brain, Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma, and Undifferentiated Pleomorphic Sarcoma. He is board certified in Internal Medicine and Medical Oncology and licensed to treat patients in California.

Distinguished
Highly rated in
17
conditions
Neurology

Memorial Sloan Kettering Cancer Center Physicians

353 E 68th St 
New York, NY 10065

Christian Grommes is a Neurologist in New York, New York. Dr. Grommes has been practicing medicine for over 22 years and is rated as a Distinguished doctor by MediFind in the treatment of Primary Lymphoma of the Brain. He is also highly rated in 17 other conditions, according to our data. His top areas of expertise are Brain Tumor, Primary Lymphoma of the Brain, Metastatic Brain Tumor, and Oligodendroglioma. He is board certified in Neurology and licensed to treat patients in Ohio. Dr. Grommes is currently accepting new patients.

 
 
 
 
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Distinguished
Highly rated in
25
conditions
Hematology
Hematology Oncology

Duarte

1500 E Duarte Rd 
Duarte, CA 91010

Leslie Popplewell is a Hematologist and a Hematologist Oncology doctor in Duarte, California. Dr. Popplewell has been practicing medicine for over 30 years and is rated as a Distinguished doctor by MediFind in the treatment of Primary Lymphoma of the Brain. She is also highly rated in 25 other conditions, according to our data. Her top areas of expertise are Non-Hodgkin Lymphoma, Mantle Cell Lymphoma, Diffuse Large B-Cell Lymphoma, and Follicular Lymphoma. She is board certified in Hematology and Internal Medicine and licensed to treat patients in California and Arizona.

What is the outlook (prognosis) for Primary Lymphoma of the Brain?

Without treatment, people with primary brain lymphoma survive for less than 6 months. When treated with chemotherapy, half of the patients will be in remission 10 years after being diagnosed. Survival may improve with autologous stem cell transplant.

What are the possible complications of Primary Lymphoma of the Brain?

Possible complications include:

  • Chemotherapy side effects, including low blood counts
  • Radiation side effects, including confusion, headaches, nervous system (neurologic) problems, and tissue death
  • Return (recurrence) of the lymphoma
Brain
MRI of the brain
What are the latest Primary Lymphoma of the Brain Clinical Trials?
A Phase 1 Study of Selinexor (KPT-330), A Selective XPO1 Inhibitor, in Recurrent and Refractory Pediatric Solid Tumors, Including CNS Tumors
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Rituximab, Methotrexate, Procarbazine and Vincristine Followed by High-dose Chemotherapy With Autologous Stem-cell Rescue in Newly-diagnosed Primary CNS Lymphoma (PCNSL)
What are the Latest Advances for Primary Lymphoma of the Brain?
Chronic inflammatory demyelinating polyneuropathy evolving to primary CNS lymphoma.
Primary Central Nervous System Lymphoma in a Patient on Adalimumab Therapy for Chronic Plaque Psoriasis.
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A Case of Primary Central Nervous System Lymphomatoid Granulomatosis that was Completely Ameliorated by Corticosteroid Treatment.
Who are the sources who wrote this article ?

Published Date : January 16, 2020
Published By : Luc Jasmin, MD, PhD, FRCS (C), FACS, Department of Surgery, Johnson City Medical Center, TN; St. Alexius Medical Center, Bismarck ND; Department of Neurosurgery Fort Sanders Medical Center, Knoxville TN. Department of Maxillofacial Surgery at UCSF, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. Editorial update 08/03/2020.

What are the references for this article ?

Baehring JM, Hochberg FH. Primary nervous system tumors in adults. In: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, eds. Bradley's Neurology in Clinical Practice. 7th ed. Philadelphia, PA: Elsevier; 2016:chap 74.

Grommes C, DeAngelis LM. Primary CNS lymphoma. J Clin Oncol. 2017;35(21):2410–2418. PMID: 28640701 pubmed.ncbi.nlm.nih.gov/28640701/.

National Cancer Institute website. Primary CNS lymphoma treatment (PDQ) - health professional version. www.cancer.gov/cancertopics/pdq/treatment/primary-CNS-lymphoma/HealthProfessional. Updated May 24, 2019. Accessed February 7, 2020.

National Comprehensive Cancer Network website. NCCN clinical practice guidelines in oncology (NCCN guidelines): central nervous system cancers. Version 2.2020. www.nccn.org/professionals/physician_gls/pdf/cns.pdf. Updated April 30, 2020. Accessed August 3, 2020.