Learn About Primary Orthostatic Tremor

What is the definition of Primary Orthostatic Tremor?
Primary orthostatic tremor is a rare, progressive movement disorder that causes unsteadiness when standing still, due to a rapid tremor affecting the legs and trunk. The tremor is sometimes described as having 'shaky legs,' and it improves or disappears when walking, sitting, or lying down. This may cause people with Primary orthostatic tremor to attempt to sit again or walk immediately after standing, for fear of falling. People with POT may also experience tiredness, physical exhaustion, muscle stiffness or weakness, and/or pain. The diagnosis of POT relies on a clinical exam as well as a specialized test called a surface electromyogram (EMG), which measures electrical activity in the muscles. The cause of POT is not completely understood, but the disorder is thought to involve dysfunction of the brain's ability to regulate nerve signals that control muscle activity.
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What are the alternative names for Primary Orthostatic Tremor?
  • Primary orthostatic tremor
  • OT
  • Orthostatic tremor, primary
  • POT
  • Shaky leg syndrome
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What are the latest Primary Orthostatic Tremor Clinical Trials?
Coordination of Rare Diseases at Sanford

Summary: CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help advance treatments and cures for rare diseases. The CoRDS team works with patient advocacy groups, in...

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Modulating Dysfunctional Cerebellar Activity With Low-intensity Focused Ultrasound Stimulation for Primary Orthostatic Tremor

Summary: Primary orthostatic tremor (POT) is a rare movement disorder that is manifested through high frequency tremor of weight bearing limbs. This is often accompanied by a debilitating sensation of falling. POT has been linked to abnormal activity of the cerebellum, a structure deep within the brain. However, established non-invasive brain stimulation techniques can only modulate brain activity and plas...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are the Latest Advances for Primary Orthostatic Tremor?
Primary Orthostatic Tremor: Experience of Perampanel Use in 20 Patients.
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Zona incerta deep-brain stimulation in orthostatic tremor: efficacy and mechanism of improvement.