Learn About Primary Progressive Aphasia

What is the definition of Primary Progressive Aphasia?
Primary progressive aphasia (PPA) affects a person's ability to use language to communicate. This includes loss of ability to understand or express speech (aphasia). PPA is a specific type of a more general disease called frontotemporal dementia. PPA can be classified into three distinct types: progressive non-fluent aphasia (PNFA), semantic dementia (SD), and logopenic progressive aphasia (LPA). PPA is caused by a loss of tissue (atrophy) in the area of the brain that is responsible for producing language. In some cases, this loss of tissue is caused by genetic changes (genetic changes or pathogenic variants) in the GRN gene. In these cases, the disease is inherited in an autosomal dominant manner. Diagnosis of PPA is suspected when a doctor observes signs and symptoms such as progressive loss of language abilities. Imaging of the brain can confirm the diagnosis.
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What are the alternative names for Primary Progressive Aphasia?
  • Primary progressive aphasia
  • Aphasia, primary progressive
  • PPA
  • Primary progressive aphasia syndrome
Who are the top Primary Progressive Aphasia Local Doctors?
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What are the latest Primary Progressive Aphasia Clinical Trials?
Communication Bridge: A Person-centered Internet-based Intervention for Individuals With Primary Progressive Aphasia
Summary: This study will use a randomized controlled trial design to evaluate the effect of two evidence-based treatments for adults with mild Primary Progressive Aphasia (PPA). The aim of the study is to help us better understand the effects of speech language therapy on communication abilities in individuals with PPA.~Participants with a diagnosis of PPA and their actively-engaged care partners will be i...
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Treatment of Word Finding Difficulties and Verbal Retrieval Deficits in Civilians Who Sustain a Chronic Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation
Summary: The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., pre-supplementary motor area) thought to aid in memory will improve verbal retrieval in civilian (non-military, non-veteran) participants with histories of traumatic brain injuries. The primary outcome measures are neuropsychological ass...
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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are the Latest Advances for Primary Progressive Aphasia?
Noninvasive brain stimulation to augment language therapy for primary progressive aphasia.
Summary: Noninvasive brain stimulation to augment language therapy for primary progressive aphasia.
History of aphasia: A broad overview.
Summary: History of aphasia: A broad overview.
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Clinical and neuroimaging characteristics of primary progressive aphasia.
Summary: Clinical and neuroimaging characteristics of primary progressive aphasia.