Primary Progressive Aphasia
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Learn About Primary Progressive Aphasia

What is the definition of Primary Progressive Aphasia?
Primary progressive aphasia (PPA) affects a person's ability to use language to communicate. This includes loss of ability to understand or express speech (aphasia). PPA is a specific type of a more general disease called frontotemporal dementia. PPA can be classified into three distinct types: progressive non-fluent aphasia (PNFA), semantic dementia (SD), and logopenic progressive aphasia (LPA). PPA is caused by a loss of tissue (atrophy) in the area of the brain that is responsible for producing language. In some cases, this loss of tissue is caused by genetic changes (genetic changes or pathogenic variants) in the GRN gene. In these cases, the disease is inherited in an autosomal dominant manner. Diagnosis of PPA is suspected when a doctor observes signs and symptoms such as progressive loss of language abilities. Imaging of the brain can confirm the diagnosis.
What are the alternative names for Primary Progressive Aphasia?
  • Primary progressive aphasia
  • Aphasia, primary progressive
  • PPA
  • Primary progressive aphasia syndrome
Who are the top Primary Progressive Aphasia Local Doctors?
Elite in Primary Progressive Aphasia
Elite in Primary Progressive Aphasia
Referral required

Johns Hopkins Outpatient Center

601 North Caroline Street, Floor 5, Floor 5, 
Baltimore, MD 
Languages Spoken:
English
Offers Telehealth

Dr. Argye Hillis is a professor of Neurology, with joint faculty appointments in Physical Medicine and Rehabilitation and in Cognitive Science. She is also the Sheikh Khalifa Stroke Institute Professor of Acute Stroke Diagnoses and Management. Prior to medical training and neurology residency, Dr. Hillis worked as a speech-language pathologist, and conducted clinical research focusing on understanding and treating aphasia and hemispatial neglect. She has brought these areas of experience to impact on her clinical research in neurology, which involves cognitive and neuroimaging studies of aphasia and hemispatial neglect due to acute stroke and focal dementias. She has published extensively on these topics in journals and textbooks. Dr. Hillis is Associate Editor of Stroke and has served as Associate editor of Brain, Annals of Neurology, Aphasiology, American Journal of Speech-Language Pathology, Neurocase, Cognitive Neuropsychology, and Language and Cognitive Processes and served as co-Editor and Chief of Behavioral Neurology. Dr. Hillis serves as the Executive Vice Chair of the Department of Neurology and the Director of the Cerebrovascular Division of Neurology at Johns Hopkins. Dr. Hillis is rated as an Elite provider by MediFind in the treatment of Primary Progressive Aphasia. She is also highly rated in 11 other conditions, according to our data. Her clinical expertise encompasses Primary Progressive Aphasia, Stroke, Frontotemporal Dementia, Thrombectomy, and Gastrostomy. Dr. Hillis is board certified in American Board Of Psychiatry And Neurology.

Elite in Primary Progressive Aphasia
Elite in Primary Progressive Aphasia
Referral may be required

Memory And Aging Center

1651 Fourth St., Suite 212, 
San Francisco, CA 
Languages Spoken:
English
Accepting New Patients
Offers Telehealth

Dr. Zachary Miller is a neurologist who specializes in caring for patients suffering from cognitive decline or dementia, including such conditions as Alzheimer's disease, frontotemporal dementia and corticobasal degeneration. In his research, Miller is particularly interested in identifying early risk factors for cognitive decline. He also studies the enhanced creativity and visual function that sometimes occurs in neurodegenerative disease. Miller earned his medical degree at the University of Pittsburgh. He completed a residency in neurology at the University of Washington, followed by a fellowship at the UCSF Memory and Aging Center. Miller is a clinical instructor in neurology at UCSF. He is a member of the American Academy of Neurology. Dr. Miller is rated as an Elite provider by MediFind in the treatment of Primary Progressive Aphasia. He is also highly rated in 12 other conditions, according to our data. His clinical expertise encompasses Primary Progressive Aphasia, Frontotemporal Dementia, Dementia, and Developmental Reading Disorder. Dr. Miller is board certified in American Board Of Psychiatry And Neurology., Neurology. Dr. Miller is currently accepting new patients.

 
 
 
 
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Elite in Primary Progressive Aphasia
Elite in Primary Progressive Aphasia
Referral may be required

Memory And Aging Center

1651 Fourth St., Suite 212, 
San Francisco, CA 
Languages Spoken:
English
Accepting New Patients

Dr. Maria Luisa Gorno-Tempini is a neurologist at the UCSF Memory and Aging Center. Her goal in patient care is to use state-of the-art cognitive and imaging techniques to diagnose and treat neurological disorders. She places a particular emphasis on managing dementia and neurodegenerative disorders. Gorno-Tempini's main research interest is progressive aphasia, impaired ability to speak or understand language. Gorno-Tempini completed her medical degree and specialty training in neurology in Italy, with a focus on behavioral neurology. She worked for three years in the Functional Imaging Laboratory at University College London, where she also earned a doctorate in imaging neuroscience. Dr. Gorno is rated as an Elite provider by MediFind in the treatment of Primary Progressive Aphasia. She is also highly rated in 15 other conditions, according to our data. Her clinical expertise encompasses Primary Progressive Aphasia, Dementia, Frontotemporal Dementia, and Developmental Reading Disorder. Dr. Gorno is currently accepting new patients.

What are the latest Primary Progressive Aphasia Clinical Trials?
Stimulating the Aging Brain: Noninvasive Brain and Sensory Stimulation Strategies in Aging

Summary: The goal of this project is to investigate whether transcranial electrical stimulation and sensory stimulation affect language outcomes in individuals with primary progressive aphasia (PPA). The main questions it aims to answer are: Does transcranial alternating current stimulation (tACS) affect verbal short-term memory (STM) in individuals with PPA? Does a single session of multisensory stimulati...

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Cognitive Reserve and Linguistic Resilience in Bilingual Hispanics With Primary Progressive Aphasia

Summary: Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA who only speak one language (monolinguals), there is a significant need for investigating the effects of treatment that is optimized for bilingual speakers with PPA. This ...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center