LONG-TERM EFFECT OF TRANSCRANIAL MAGNETIC STIMULATION AND TRANSCRANIAL ELECTRICAL STIMULATION IN PRIMARY PROGRESSIVE APHASIA: RANDOMIZED, DOUBLE-BLIND CLINICAL TRIAL (RECONNECT-PLUS)
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The goal of this clinical trial is to investigate the effect of non-invasive brain stimulation techniques in the progression of primary progressive aphasia for 6 months. We will compare three modalities of brain stimulation (TMS, tDCS, TMS+tDCS) against sham stimulation. All patients will receive also language therapy.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Diagnosis of PPA according to the current consensus criteria supported by neuroimaging (FDG-PET or MRI) (Gorno-Tempini et al., 2011);
• Clinical Dementia Rating scale equal or less than 1;
• The language impairment is the main neurological deficit for the patient.
Locations
Other Locations
Spain
Hospital Clinico San Carlos
RECRUITING
Madrid
Contact Information
Primary
Jordi Matias-Guiu, PhD MD
jordi.matias-guiu@salud.madrid.org
+34913303000
Time Frame
Start Date: 2025-09-15
Estimated Completion Date: 2028-12
Participants
Target number of participants: 80
Treatments
Experimental: active TMS + active tDCS
Experimental: active TMS + sham tDCS
Experimental: sham TMS + active tDCS
Sham_comparator: sham TMS + sham tDCS
Related Therapeutic Areas
Sponsors
Leads: Hospital San Carlos, Madrid