Learn About Proctitis

What is the definition of Proctitis?

Proctitis is an inflammation of the rectum. It can cause discomfort, bleeding, and the discharge of mucus or pus.

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What are the alternative names for Proctitis?

Inflammation - rectum; Rectal inflammation

What are the causes of Proctitis?

There are many causes of proctitis. They can be grouped as follows:

  • Inflammatory bowel disease
  • Autoimmune disease
  • Harmful substances
  • Non-sexually transmitted infection
  • Sexually transmitted disease (STD)

Proctitis caused by STD is common in people who have anal intercourse. STDs that can cause proctitis include gonorrhea, herpes, chlamydia, and lymphogranuloma venereum.

Infections that are not sexually transmitted are less common than STD proctitis. One type of proctitis not from an STD is an infection in children that is caused by the same bacteria as strep throat.

Autoimmune proctitis is linked to diseases such as ulcerative colitis or Crohn disease. If the inflammation is in the rectum only, it may come and go or move upward into the large intestine.

Proctitis may also be caused by some medicines, radiotherapy to prostate or pelvis or inserting harmful substances into the rectum.

Risk factors include:

  • Autoimmune disorders, including inflammatory bowel disease
  • High-risk sexual practices, such as anal sex
What are the symptoms of Proctitis?

Symptoms include:

  • Bloody stools
  • Constipation
  • Rectal bleeding
  • Rectal discharge, pus
  • Rectal pain or discomfort
  • Tenesmus (pain with bowel movement)
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What are the current treatments for Proctitis?

Most of the time, proctitis will go away when the cause of the problem is treated. Antibiotics are used if an infection is causing the problem.

Corticosteroids or mesalamine suppositories or enemas may relieve symptoms for some people.

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What is the outlook (prognosis) for Proctitis?

The outcome is good with treatment.

What are the possible complications of Proctitis?

Complications may include:

  • Anal fistula
  • Anemia
  • Recto-vaginal fistula (women)
  • Severe bleeding
When should I contact a medical professional for Proctitis?

Call your health care provider if you have symptoms of proctitis.

How do I prevent Proctitis?

Safe sex practices may help prevent the spread of the disease.

Digestive system
What are the latest Proctitis Clinical Trials?
Transverse Colostomy for Refractory Hemorrhagic Chronic Radiation Proctitis With Moderate to Severe Anemia: a Prospective Cohort Study

Summary: Refractory rectal bleeding of chronic radiation proctitis (CRP) is still problematic and does not respond to medical treatments including reagents, endoscopic argon plasma coagulation (APC) or topical formalin. We proposed this prospective cohort study, to assess the efficacy and safety of colostomy in treating refractory hemorrhagic CRP with moderate to severe anemia, to provide higher-quality ev...

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A Multicenter Randomized Controlled Stage III Clinical Study of Dendrobium Huoshanense Suppository in Locally Advanced Rectal Cancer Patients Treated by Neoadjuvant Chemoradiotherapy

Summary: To evaluates the role of Dendrobium Huoshanense Suppository for radiation proctitis in locally advanced rectal cancer treated by capecitabine and irinotecan based neoadjuvant chemoradiation.

What are the Latest Advances for Proctitis?
Hyperbaric oxygen treatment for late radiation-induced tissue toxicity in treated gynaecological cancer patients: a systematic review.
Tacrolimus (FK506) for induction of remission in corticosteroid-refractory ulcerative colitis.
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A case of ischemic proctitis caused by impaired venous blood flow 11 months after surgery for sigmoid colon cancer.
Who are the sources who wrote this article ?

Published Date: April 21, 2021
Published By: Michael M. Phillips, MD, Emeritus Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Centers for Disease Control and Prevention website. 2021 Sexually Transmitted Diseases Treatment Guidelines. www.cdc.gov/std/treatment-guidelines/proctitis.htm. Reviewed July 22, 2021. Accessed August 11, 2021.

Coates WC. Disorders of the anorectum. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 86.

Downs JM, Kulow B. Anal diseases. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 129.

National Institute of Diabetes and Digestive and Kidney Diseases website. Proctitis. www.niddk.nih.gov/health-information/digestive-diseases/proctitis/all-content. Updated August 2016. Accessed August 11, 2021.