Effect of Bilirubin on Prognosis in Heart Failure With Preserved Ejection Fraction
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
Factors influencing the prognosis of patients with heart failure with preserved ejection fraction (HFpEF) have been extensively studied. Previous studies have found that elevated serum total bilirubin levels are associated with cardiac death, heart failure readmission, and all-cause mortality in patients with chronic heart failure. However, the relationship between direct bilirubin and prognosis in patients with HFpEF is unclear.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Adult aged ≥18 years old；
• Diagnosed with HFpEF.
‣ Diagnostic criteria including:
⁃ left ventricular ejection fraction ≥ 50%;
⁃ with the symptoms and/or signs of heart failure;
⁃ Patients in sinus rhythm：BNP≥35pg/ml and/or NT-proBNP≥125pg/ml；Patients with atrial fibrillation：BNP≥105pg/ml and/or NT-proBNP≥365pg/ml.
Locations
Other Locations
China
The First Affiliated Hospital of Chongqing Medical University
RECRUITING
Chongqing
Contact Information
Primary
Dongying Zhang, doctor
zdy.chris@qq.com
+8613608398395
Time Frame
Start Date: 2020-09-20
Estimated Completion Date: 2024-07-01
Participants
Target number of participants: 400
Treatments
DB≤6.8µmol/L
heart failure with preserved ejection fraction patients with direct bilirubn ≤6.8µmol/L
DB>6.8µmol/L
heart failure with preserved ejection fraction patients with direct bilirubn \>6.8µmol/L
Related Therapeutic Areas
Sponsors
Leads: Chongqing Medical University