What is the definition of Progressive Myoclonic Epilepsy?

Progressive myoclonus epilepsy (PME) refers to a group of inherited conditions involving the central nervous system and representing more than a dozen different diseases. These diseases share certain features, including a worsening of symptoms over time and the presence of both muscle contractions (myoclonus) and seizures (epilepsy). PME is different from myoclonic epilepsy. Other features include dementia, dystonia, and trouble walking or speaking. These rare disorders often get worse over time and sometimes are fatal. Many of these PME diseases begin in childhood or adolescence.

What are the alternative names for Progressive Myoclonic Epilepsy?

  • Familial progressive myoclonic epilepsy
  • Journal: BMJ case reports
  • Published —
Lafora body disease: a case of progressive myoclonic epilepsy.
  • Condition: Congenital Generalized Lipodystrophy (CGL) with Progressive Myoclonic Epilepsy
  • Journal: Medicine
  • Treatment Used: Sodium Valproate, Baclofen, Aripiprazole, Benzhexol, Lamotrigine, and Nutrition Therapy
  • Number of Patients: 1
  • Published —
This case report discusses a child with congenital generalized lipodystrophy (CGL), a rare autosomal recessive hereditary disease, associated with metabolic complications and epilepsy, which is also rare.

There are no recent clinical trials available for this condition. Please check back because new trials are being conducted frequently.