Learn About Progressive Osseous Heteroplasia

What is the definition of Progressive Osseous Heteroplasia?

Progressive osseous heteroplasia is a disorder in which bone forms within skin and muscle tissue. Bone that forms outside the skeleton is called heterotopic or ectopic bone. In progressive osseous heteroplasia, ectopic bone formation begins in the deep layers of the skin (dermis and subcutaneous fat) and gradually moves into other tissues such as skeletal muscle and tendons. The bony lesions within the skin may be painful and may develop into open sores (ulcers). Over time, joints can become involved, resulting in impaired mobility.

Save information for later
Sign Up
What are the causes of Progressive Osseous Heteroplasia?

Progressive osseous heteroplasia is caused by a mutation in the GNAS gene. The GNAS gene provides instructions for making one part of a protein complex called a guanine nucleotide-binding protein, or a G protein.

How prevalent is Progressive Osseous Heteroplasia?

Progressive osseous heteroplasia is a rare condition. Its exact incidence is unknown.

Is Progressive Osseous Heteroplasia an inherited disorder?

This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.

Who are the top Progressive Osseous Heteroplasia Local Doctors?
Learn about our expert tiers
Learn more
What are the latest Progressive Osseous Heteroplasia Clinical Trials?
Match to trials
Find the right clinical trials for you in under a minute
Get started
Who are the sources who wrote this article ?

Published Date: February 01, 2018Published By: National Institutes of Health

What are the Latest Advances for Progressive Osseous Heteroplasia?

There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.