Progressive Osseous HeteroplasiaSymptoms, Doctors, Treatments, Advances & More
Learn About Progressive Osseous Heteroplasia
Progressive osseous heteroplasia is a disorder in which bone forms within skin and muscle tissue. Bone that forms outside the skeleton is called heterotopic or ectopic bone. In progressive osseous heteroplasia, ectopic bone formation begins in the deep layers of the skin (dermis and subcutaneous fat) and gradually moves into other tissues such as skeletal muscle and tendons. The bony lesions within the skin may be painful and may develop into open sores (ulcers). Over time, joints can become involved, resulting in impaired mobility.
Progressive osseous heteroplasia is caused by a mutation in the GNAS gene. The GNAS gene provides instructions for making one part of a protein complex called a guanine nucleotide-binding protein, or a G protein.
Progressive osseous heteroplasia is a rare condition. Its exact incidence is unknown.
This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.
Ballad Health Medical Associates Associated Orthopedics
Originally from Big Bear, a small ski resort town in Southern California, Todd Horton, MD, moved to the Appalachian Highlands after retiring from the U.S. Navy in Portsmouth, Virginia. He was drawn to the region for its scenic rural charm, convenient access to amenities and the warmth of its small-town feel. Dr. Horton specializes in upper extremity and hand surgery with a focus on restoring function through precise mechanical repair. He enjoys helping patients recover from injuries and regain the strength and confidence to return to their everyday lives. In his free time, Dr. Horton enjoys precision and tactical shooting, motorsports and taking part in local organizations including VictorySports MotoCross, the South East Trail Riders Association and regional rodeo and gun clubs. Dr. Horton is rated as a Distinguished provider by MediFind in the treatment of Progressive Osseous Heteroplasia. His top areas of expertise are Progressive Osseous Heteroplasia, Fibrodysplasia Ossificans Progressiva, Osteoarthritis, and Carpal Tunnel Syndrome.
Penn Orthopaedics University City - 8th Floor
Frederick Kaplan is an Orthopedics provider in Philadelphia, Pennsylvania. Dr. Kaplan is rated as an Elite provider by MediFind in the treatment of Progressive Osseous Heteroplasia. His top areas of expertise are Fibrodysplasia Ossificans Progressiva, Progressive Osseous Heteroplasia, Compartment Syndrome, Brachydactyly Mononen Type, and Fasciotomy.
Giovanna Mantovani practices in Sao Paulo, Brazil. Ms. Mantovani is rated as an Elite expert by MediFind in the treatment of Progressive Osseous Heteroplasia. Her top areas of expertise are Albright's Hereditary Osteodystrophy, Pseudohypoparathyroidism, Progressive Osseous Heteroplasia, Hormone Replacement Therapy (HRT), and Endoscopic Transnasal Transsphenoidal Surgery.
Published Date: February 01, 2018
Published By: National Institutes of Health