Learn About Progressive Supranuclear Palsy Atypical

What is the definition of Progressive Supranuclear Palsy Atypical?

Progressive supranuclear palsy (PSP) is a movement disorder that occurs from damage to certain nerve cells in the brain.

Save information for later
Sign Up
What are the alternative names for Progressive Supranuclear Palsy Atypical?

Dementia - nuchal dystonia; Richardson-Steele-Olszewski syndrome; Palsy - progressive supranuclear

What are the causes of Progressive Supranuclear Palsy Atypical?

PSP is a condition that causes symptoms similar to those of Parkinson disease.

It involves damage to many cells of the brain. Many areas are affected, including the part of the brainstem where cells that control eye movement are located. The area of the brain that controls steadiness when you walk is also affected. The frontal lobes of the brain are also affected, leading to personality changes.

The cause of the damage to the brain cells is unknown. PSP gets worse over time.

People with PSP have deposits in brain tissues that look like those found in people with Alzheimer disease. There is a loss of tissue in most areas of the brain and in some parts of the spinal cord.

The disorder is most often seen in people over 60 years old, and is somewhat more common in men.

What are the symptoms of Progressive Supranuclear Palsy Atypical?

Symptoms may include any of the following:

  • Loss of balance, repeated falls
  • Lunging forward when moving, or fast walking
  • Bumping into objects or people
  • Changes in expressions of the face
  • Deeply lined face
  • Eye and vision problems such as different sized pupils, difficulty moving the eyes (supranuclear ophthalmoplegia), lack of control over the eyes, problems keeping the eyes open
  • Difficulty swallowing
  • Tremors, jaw or face jerks or spasms
  • Mild-to-moderate dementia
  • Personality changes
  • Slow or stiff movements
  • Speech difficulties, such as low voice volume, not able to say words clearly, slow speech
  • Stiffness and rigid movement in the neck, middle of the body, arms, and legs
Not sure about your diagnosis?
Check Your Symptoms
What are the current treatments for Progressive Supranuclear Palsy Atypical?

The goal of treatment is to control symptoms. There is no known cure for PSP.

Medicines such as levodopa may be tried. These drugs raise the level of a brain chemical called dopamine. Dopamine is involved in the control of movement. The medicines may reduce some symptoms, such as rigid limbs or slow movements for a time. But they are usually not as effective as they are for Parkinson disease.

Many people with PSP will eventually need around-the-clock care and monitoring as they lose brain functions.

Who are the top Progressive Supranuclear Palsy Atypical Local Doctors?
Elite
Highly rated in
22
conditions
Neurology

University of California San Francisco Health System

Memory And Aging Center

1651 4th St 
San Francisco, CA 

Adam Boxer is a Neurologist in San Francisco, California. Boxer has been practicing medicine for over 24 years and is rated as an Elite expert by MediFind in the treatment of Progressive Supranuclear Palsy Atypical. He is also highly rated in 22 other conditions, according to our data. His top areas of expertise are Frontotemporal Dementia, Progressive Supranuclear Palsy, Progressive Supranuclear Palsy Atypical, and Supranuclear Ophthalmoplegia. He is licensed to treat patients in California.

Elite
Highly rated in
17
conditions

Hannover Medical School

Hannover, NI, DE 

Gunter Hoglinger practices in Hannover, Germany. Hoglinger is rated as an Elite expert by MediFind in the treatment of Progressive Supranuclear Palsy Atypical. They are also highly rated in 17 other conditions, according to our data. Their top areas of expertise are Supranuclear Ophthalmoplegia, Progressive Supranuclear Palsy, Progressive Supranuclear Palsy Atypical, and Brown Syndrome.

 
 
 
 
Learn about our expert tiers
Learn more
Elite
Highly rated in
25
conditions
Neurology

University of California San Diego Health System

La Jolla 4510 Executive Dr

4510 Executive Dr 
San Diego, CA 

Irene Litvan is a Neurologist in San Diego, California. Litvan has been practicing medicine for over 43 years and is rated as an Elite expert by MediFind in the treatment of Progressive Supranuclear Palsy Atypical. She is also highly rated in 25 other conditions, according to our data. Her top areas of expertise are Parkinson's Disease, Supranuclear Ophthalmoplegia, Progressive Supranuclear Palsy, and Progressive Supranuclear Palsy Atypical. She is licensed to treat patients in Kentucky. Litvan is currently accepting new patients.

What is the outlook (prognosis) for Progressive Supranuclear Palsy Atypical?

Treatment sometimes can reduce symptoms for a while, but the condition will get worse. Brain function will decline over time. Death commonly occurs in 5 to 7 years.

Newer drugs are being studied to treat this condition.

What are the possible complications of Progressive Supranuclear Palsy Atypical?

Complications of PSP include:

  • Blood clot in veins (deep vein thrombosis) due to limited movement
  • Injury from falling
  • Lack of control over vision
  • Loss of brain functions over time
  • Pneumonia due to trouble swallowing
  • Poor nutrition (malnutrition)
  • Side effects from medicines
When should I contact a medical professional for Progressive Supranuclear Palsy Atypical?

Call your provider if you often fall, and if you have a stiff neck/body, and vision problems.

Also, call if a loved one has been diagnosed with PSP and the condition has declined so much that you can no longer care for the person at home.

Central nervous system and peripheral nervous system
What are the latest Progressive Supranuclear Palsy Atypical Clinical Trials?
Building Online Community to Improve Patient and Caregiver Outcomes in Parkinson Disease, Lewy Body Dementia and Related Disorders
Match to trials
Find the right clinical trials for you in under a minute
Get started
Biomarkers in Neurodegenerative Diseases
What are the Latest Advances for Progressive Supranuclear Palsy Atypical?
A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech.
Cerebellar rTMS for motor control in progressive supranuclear palsy.
Tired of the same old research?
Check Latest Advances
Treatment outcomes following continuous miglustat therapy in patients with Niemann-Pick disease Type C: a final report of the NPC Registry.
Who are the sources who wrote this article ?

Published Date: June 23, 2020
Published By: Amit M. Shelat, DO, FACP, FAAN, Attending Neurologist and Assistant Professor of Clinical Neurology, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Jankovic J. Parkinson disease and other movement disorders. In: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, eds. Bradley's Neurology in Clinical Practice. 7th ed. Philadelphia, PA: Elsevier; 2016:chap 96.

Ling H. Clinical approach to progressive supranuclear palsy. J Mov Disord. 2016;9(1):3-13. PMID: 26828211 pubmed.ncbi.nlm.nih.gov/26828211/.

National Institute of Neurological Disorders website. Progressive supranuclear palsy fact sheet. www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Progressive-Supranuclear-Palsy-Fact-Sheet. Updated March 17, 2020. Accessed August 19, 2020.