Integrating Tissue-based Spatial Information to Elucidate How Obesity-induced Tumour Metabolites Drive Prostate Cancer Progression

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1/-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight/obese (BMI \> 27.5) and non-severely overweight/normoweight (BMI \< 27.5) patients affected by prostate carcinoma. ii. Characterize the immune infiltrate in the prostate carcinoma of the aforementioned patients. iii. Assess the association between intra-tumoral lactate accumulation (using LDHA and MCT-4 protein expression levels as readouts) and alterations in the tumor immune microenvironment and/or deregulation of relevant oncogenic pathways.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 18
Healthy Volunteers: f
View:

• affected by prostate cancer

Locations
Other Locations
Italy
IRCCS Cà Granda Ospedale Maggiore Policlinico Milano
RECRUITING
Milan
Contact Information
Primary
Giancarlo Albo, MD,
giancarlo.albo@policlinico.mi.it
00390255034501
Time Frame
Start Date: 2023-03-20
Estimated Completion Date: 2027-01-15
Participants
Target number of participants: 25
Treatments
obese individuals [Body Mass Index (BMI) > 30 affected by prostate cancer
normal-weight individuals [18 < BMI < 25] affected by prostate cancer
Related Therapeutic Areas
Sponsors
Leads: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Collaborators: National Research Council

This content was sourced from clinicaltrials.gov