Learn About Protein S Deficiency

What is the definition of Protein S Deficiency?

Protein S deficiency is a disorder of blood clotting. People with this condition have an increased risk of developing abnormal blood clots.

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What are the causes of Protein S Deficiency?

Protein S deficiency is caused by mutations in the PROS1 gene. This gene provides instructions for making protein S, which is found in the bloodstream and is important for controlling blood clotting. Protein S helps block the activity of (inactivate) certain proteins that promote the formation of blood clots.

How prevalent is Protein S Deficiency?

Mild protein S deficiency is estimated to occur in approximately 1 in 500 individuals. Severe protein S deficiency is rare; however, its exact prevalence is unknown.

Is Protein S Deficiency an inherited disorder?

Protein S deficiency is inherited in an autosomal dominant pattern, which means one altered copy of the PROS1 gene in each cell is sufficient to cause mild protein S deficiency. Individuals who inherit two altered copies of this gene in each cell have severe protein S deficiency.

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Who are the sources who wrote this article ?

Published Date: October 01, 2009Published By: National Institutes of Health

What are the Latest Advances for Protein S Deficiency?
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