• Males and females, ≥18 years of age.

• Diagnosis of Prurigo Nodularis by a dermatologist at least 3 months prior to Screening with:

‣ At least 20 PN nodules with bilateral distribution on both arms and/or both legs and/or both sides of the trunk at screening.

⁃ An Investigators Global Assessment for stage of chronic nodular prurigo (IGA-CNPG-S) score for PN ≥ 3 at screening and Baseline (Day 1).

• Severe itch, defined as the mean of the daily worst itch NRS (WI-NRS) score of ≥ 7 during the 7-day period immediately prior to initiation of study treatment.

• Documented history of inadequate response to prescription topical medications or for whom topical medications are medically inadvisable.

• Willing to apply a topical moisturizer (emollient) once or twice a day throughout the study.

• Both males and females of child-bearing potential must agree to use highly effective contraceptives during the study and for 150 days afterwards after treatment.

• Willing and able to complete a daily symptom electronic diary for the duration of the study and adhere to the study visit schedule.