Prurigo Nodularis Clinical Trials

• Voluntarily sign informed consent forms before any investigational procedure(s) are performed.

• Male or female aged between 18 and 75 years at the time of signing the informed consent.

• Clinical diagnosis of PN by a dermatologist for at least 3 months before the Screening visit.

• At least 20 pruriginous lesions on the entire body with a bilateral distribution (on both legs, and/or both arms and/or trunk) at both screening and the baseline (Day 1) visits.

• PP NRS score ≥ 7 at both screening and the baseline (Day 1) visits.

• IGA-CPG-S score ≥ 3 at both the screening and the baseline (Day 1) visits.

• History of inadequate response to topical corticosteroid of medium or higher potency or for whom topical treatments are otherwise medically inadvisable (e.g., because of important side effects or safety risks).

⁃ Willingness to avoid pregnancy or fathering children