Role of Clonal Hematopoiesis and NETs Formation in Unusual Venous Thrombosis (CLODETTE)

Status: Recruiting
Location: See all (7) locations...
Intervention Type: Biological
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Thrombo-embolic venous diseases are represented by deep venous thrombosis and/or pulmonary embolism. In some patients with repeated thrombosis or occurrence of thrombosis in unusual sites, the etiological workup remains negative, which represents a problem for the management of the anticoagulant treatments. Recently, two factors have been identified as important in the physiopathology of hemostasis and coagulation: the presence of clonal hematopoiesis of indetermined potential (CHIP) and the formation of neutrophil extracellular traps (NETs). In this study, these two factors will be studied in patients with repeated venous thrombosis or thrombosis occurring in unusual site.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 6
Maximum Age: 50
Healthy Volunteers: f
View:

• Patients (male or female) less than 50 y.o with :

• Splanchnic venous territory thrombosis or

• Cerebral venous thrombosis or

• Venous thrombosis of the upper limb or

• Pulmonary embolism (1st episode if male, 2nd episode if female) unprovoked or

• 1 episode of deep vein thrombosis + 1 episode of arterial thrombosis

Locations
Other Locations
France
CHU de Bordeaux, Service de Neurologie
NOT_YET_RECRUITING
Bordeaux
CHU de Bordeaux, Service Gastro-Entérologie
NOT_YET_RECRUITING
Bordeaux
CHU de Bordeaux, Service Hématologie Biologique
RECRUITING
Bordeaux
CHU de Bordeaux, Service Médecine Vasculaire
RECRUITING
Bordeaux
CHU de Bordeaux, Unité ambulatoire de Médecine Vasculaire
RECRUITING
Bordeaux
CHU de Lille, Service Hémostase Clinique
NOT_YET_RECRUITING
Lille
APHM - Hôpital de la Timone, Service Hématologie
NOT_YET_RECRUITING
Marseille
Contact Information
Primary
Alexandre GUY
alexandre.guy@chu-bordeaux.fr
0557656478
Backup
Chloé JAMES
chloe.james@chu-bordeaux.fr
0557891979
Time Frame
Start Date: 2023-03-03
Estimated Completion Date: 2027-03
Participants
Target number of participants: 150
Sponsors
Leads: University Hospital, Bordeaux

This content was sourced from clinicaltrials.gov