What is the definition of Pulmonary Nocardiosis?

Pulmonary nocardiosis is an infection of the lung with the bacteria, Nocardia asteroides.

What are the alternative names for Pulmonary Nocardiosis?

Nocardiosis - pulmonary; Mycetoma; Nocardia

What are the causes for Pulmonary Nocardiosis?

Nocardia infection develops when you breathe in (inhale) the bacteria. The infection causes pneumonia-like symptoms. The infection can spread to any part of the body.

People with a weak immune system are at a high risk for nocardia infection. This includes people who have:

  • Been taking steroids or other medicines that weaken the immune system for a long time
  • Cushing disease
  • An organ transplant
  • HIV/AIDS
  • Lymphoma

Other people at risk include those with long-term (chronic) lung problems related to smoking, emphysema, or tuberculosis.

What are the symptoms for Pulmonary Nocardiosis?

Pulmonary nocardiosis mainly affects the lungs. But, it can also spread to other organs in the body. Common symptoms may include:

ENTIRE BODY

  • Fever (comes and goes)
  • General ill feeling (malaise)
  • Night sweats

GASTROINTESTINAL SYSTEM

  • Nausea
  • Liver and spleen swelling (hepatosplenomegaly)
  • Loss of appetite
  • Unintentional weight loss
  • Vomiting

LUNGS AND AIRWAYS

  • Breathing difficulty
  • Chest pain not due to heart problems
  • Coughing up blood or mucus
  • Rapid breathing
  • Shortness of breath

MUSCLES AND JOINTS

  • Joint pain

NERVOUS SYSTEM

  • Change in mental state
  • Confusion
  • Dizziness
  • Headache
  • Seizures
  • Changes in vision

SKIN

  • Skin rashes or lumps
  • Skin sores (abscesses)
  • Swollen lymph nodes

What are the current treatments for Pulmonary Nocardiosis?

The goal of treatment is to control the infection. Antibiotics are used, but it may take a while to get better. Your provider will tell you how long you need to take the medicines. This may be for up to a year.

Surgery may be needed to remove or drain infected areas.

Your provider may tell you to stop taking any medicines that weaken your immune system. Never stop taking any medicine before talking to your provider first.

What is the outlook (prognosis) for Pulmonary Nocardiosis?

The outcome is often good when the condition is diagnosed and treated quickly.

The outcome is poor when the infection:

  • Spreads outside the lung.
  • Treatment is delayed.
  • The person has a serious disease that leads to or requires long-term suppression of the immune system.

What are the possible complications for Pulmonary Nocardiosis?

Complications of pulmonary nocardiosis may include:

  • Brain abscesses
  • Skin infections
  • Kidney infections

When should I contact a medical professional for Pulmonary Nocardiosis?

Call your provider if you have symptoms of this disorder. Early diagnosis and treatment may improve the chance of a good outcome.

How do I prevent Pulmonary Nocardiosis?

Be careful when using corticosteroids. Use these medicines sparingly, in the lowest effective doses and for the shortest periods of time possible.

Some people with a weak immune system may need to take antibiotics for long periods of time to prevent the infection from returning.

Respiratory

REFERENCES

Southwick FS. Nocardiosis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 314.

Torres A, Menéndez R, Wunderink RG. Bacterial pneumonia and lung abscess. In: Broaddus VC, Mason RJ, Ernst JD, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 33.

  • Condition: Cutaneous Infection caused by N. Takedensis
  • Journal: Annals of clinical microbiology and antimicrobials
  • Treatment Used: Trimethoprim-Sulfamethoxazole
  • Number of Patients: 2
  • Published —
The study researched the outcomes of Trimethoprim-Sulfamethoxazole antibiotic therapy in patients with cutaneous infection caused by N. takedensis.
  • Condition: Plantar Actinomycetoma
  • Journal: Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia
  • Treatment Used: 24-Weeks Doxycycline Regime
  • Number of Patients: 1
  • Published —
This case report describes a patient with plantar actinomycetoma (fungal foot infection) without risk factors treated with a 24-weeks doxycycline regime.

There are no recent clinical trials available for this condition. Please check back because new trials are being conducted frequently.