What is the definition of Punctate Porokeratosis?

Punctate porokeratosis is a skin condition that appears in adulthood as many, tiny, ridgelike bumps on the palms of the hands and soles of the feet.  These bumps may slowly spread over the skin and usually do not cause symptoms, though they sometimes cause itching or discomfort while walking.  Individuals with this condition often develop other types of porokeratosis as well.  The cause of punctate porokeratosis is unknown, though genetic factors, a weakened immune system (immunodeficiency), or previous injury to the skin (for example, a burn) have been suggested as possible risk factors.   Treatment depends on the size, location, and aggressiveness of porokeratosis in each affected individual; it may include observation only, medication, or surgery.

What are the alternative names for Punctate Porokeratosis?

  • PPPP
  • Porokeratosis punctata palmaris et plantaris

What are the current treatments for Punctate Porokeratosis?

Treatment depends on the size, location, and aggressiveness of punctate porokeratosis.  Affected individuals are recommended to visit their personal physician regularly to watch for signs of skin cancer, limit sun exposure to the affected area, and use moisturizers as needed.  5-fluorouracil cream has been found to be an effective treatment.  A group of medications called retinoids (including acitretin and isotretinoin), as a pill or cream, may be another treatment option.  If a skin cancer develops from porokeratosis, surgery is recommended.
  • Condition: Adult-onset porokeratotic eccrine ostial and dermal duct nevus
  • Journal: Dermatology online journal
  • Treatment Used: Tazarotene
  • Number of Patients: 1
  • Published —
The study reported the outcomes of Tazarotene in a patient with adult-onset porokeratotic eccrine ostial and dermal duct nevus.
  • Condition: Porokeratosis
  • Journal: Journal of drugs in dermatology : JDD
  • Treatment Used: Ablative Fractional Carbon Dioxide Laser
  • Number of Patients: 1
  • Published —
This case report describes a patient with prokeratosis that was treated using an ablative fractional carbon dioxide laser and topical vitamin C, E, and ferulic acid serum.

There are no recent clinical trials available for this condition. Please check back because new trials are being conducted frequently.