Learn About Pyoderma Gangrenosum

What is the definition of Pyoderma Gangrenosum?
Pyoderma gangrenosum is a rare, destructive inflammatory skin disease of which a painful nodule or pustule breaks down to form a progressively enlarging ulcer. Lesions may occur either in the absence of any apparent underlying disorder or in association with other diseases, such as ulcerative colitis, Crohn's disease, polyarthritis (an inflammation of several joints together), gammopathy, vasculitis, leukemia, and other conditions. Each year in the United States, Pyoderma gangrenosum occurs in about 1 person per 100,000 people. Pyoderma gangrenosum belongs to a group of autoinflammatory skin diseases called neutrophilic dermatoses. Neutrophils are a type of white blood cell or leukocyte which form an early line of defense against bacterial infections. Ulcerations associated with Pyoderma gangrenosum may occur after trauma or injury to the skin, a process called pathergy.
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What are the alternative names for Pyoderma Gangrenosum?
  • Pyoderma gangrenosum
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What are the latest Pyoderma Gangrenosum Clinical Trials?
Post-marketing Observational Study for Humira in Participants Diagnosed With Pyoderma Gangrenosum (PG)
Summary: Pyoderma Gangrenosum (PG) is a rapidly progressive disease and presents as painful, single or multiple lesions, with several clinical variants, in different locations, with a nonspecific histology, which makes the diagnosis challenging and often delayed. The main objective of this study is to estimate the incidence proportion of all the infection reported as adverse drug reaction (ADR) of Humira w...
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Hyperbaric Oxygen Therapy for Pyoderma Gangrenosum As a New Treatment Strategy
Summary: Rationale: Pyoderma gangrenosum (PG) is a rare auto-inflammatory neutrophilic dermatosis characterized by a spectrum of clinical presentations with variable courses. Diagnosis and management are challenging in PG. Treatment, including systemic prednisone and anti-TNF therapy, is directed towards reducing pain and associated inflammation that leads to ulceration. Positive effects of hyperbaric oxyg...
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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are the Latest Advances for Pyoderma Gangrenosum?
Clinical efficacy of human split-thickness skin allograft in patients with pyoderma gangrenosum: a case series.
Summary: Clinical efficacy of human split-thickness skin allograft in patients with pyoderma gangrenosum: a case series.
Current situation and the latest progress in the treatment of pyoderma gangrenosum.
Summary: Current situation and the latest progress in the treatment of pyoderma gangrenosum.
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VEXAS syndrome : when do we have to consider it ?
Summary: VEXAS syndrome : when do we have to consider it ?