Learn About REM Behavior Disorder

What is the definition of REM Behavior Disorder?
Rapid eye movement (REM) behavior disorder, also known as dream-enacting behavior, is a rare sleep disorder, or parasomnia, which involves acting out vivid, bad dreams during REM sleep by making verbal sounds along with often violent limb movements. REM behavior disorder can be associated with other neurological conditions, such as Lewy body dementia, Parkinson’s disease, or multiple system atrophy, and can occur with other sleep disorders, such as sleep apnea, periodic limb movement disorder, and narcolepsy, and usually occurs in men over the age of 50. REM behavior disorder may worsen over time. REM behavior disorder may also be related to other conditions, such as sleep deprivation, certain medications, alcohol withdrawal, brainstem tumors, and stroke.
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What are the symptoms of REM Behavior Disorder?
Symptoms of REM behavior disorder are characterized by physically acting out dreams, such as arm flailing, punching, kicking, or jumping from bed; noises, such as emotional outcries, talking, laughing, shouting, cursing; and being able to vividly recall a dream if awakened. Symptoms of REM behavior disorder may worsen over time and may cause injury to the individual or bed partner.
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What are the current treatments for REM Behavior Disorder?
Treatment for REM behavior disorder is focused on medication and providing a safe sleep environment. Medications for REM behavior disorder include the supplement, melatonin, and clonazepam (Klonopin). Safeguards to prevent injury from REM behavior disorder include floor padding, removing sharp items and weapons from the bedroom, barriers on the sides of bed, moving furniture, protecting and/or blocking windows, sleeping separately from a partner. Individuals with REM behavior disorder should avoid sleep deprivation with a regular sleeping schedule, avoid daytime sleepiness, alcohol, and some medications, treat any associated sleep disorders, and have regular evaluations for any neurological symptoms, such as tremor, that may indicate the onset of Parkinson's disease or other neurological disorders.
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What are the latest REM Behavior Disorder Clinical Trials?
A Natural History Analysis of Rapid Eye Movement Sleep Behavior Disorder as Prognostic for Parkinson's Disease

Summary: Purpose - to validate a combination of biological and clinical markers in the rapid-eye-movement (REM) sleep behavior disorder (RBD) population as indicative of the pre-symptomatic stage of Parkinson's disease (PD). Procedures - All subjects (RBD diagnosis and controls) will have 1) a medical and neuro history and physical including videotape of movements, 2) neuropsychological testing, 3) a sleep...

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Study on Disease Course and Quality of Life in Patients With Sleep Disorders (Mainz Sleep Registry)

Summary: Prospective longitudinal observational registry study of all patients with sleep disorders treated in the Mainz Comprehensive Epilepsy and Sleep Medicine Center with the focus on the course of the disease and quality of life.

What are the Latest Advances for REM Behavior Disorder?
Melatonin for rapid eye movement sleep behavior disorder in Parkinson's disease: A randomised controlled trial.
Effects of bilateral stimulation of the subthalamic nucleus in Parkinson's disease with and without REM sleep behaviour disorder.
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