A Prospective, Open-label, Single-center Study of CD70-Specific PET/CT Imaging for Non-invasive Diagnosis of Renal Cell Carcinoma
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This is a prospective, open-label, single-center clinical study targeting renal cell carcinoma. Sixty patients with a high clinical suspicion of renal cell carcinoma were included. Qualified subjects will undergo 68Ga-NOTA-RCCB6 PET/CT examination. The aim is to establish the optimal imaging protocol; evaluate the distribution characteristics and correlations of physiological and pathological positive uptake, and using pathological results as the gold standard, assess the diagnostic efficacy of 68Ga-NOTA-RCCB6 PET/CT in renal cell carcinoma.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
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• \- The subject or legal guardian/caregiver must voluntarily sign the informed consent form.
• Ages 18 to 75 years old. Patients with suspected renal cell carcinoma based on conventional imaging studies, and who undergo 68Ga-PSMA PET/CT scanning.
• Patients with suspicious lymph nodes or distant metastases detected by conventional imaging or 68Ga-PSMA PET/CT.
• Willing and able to follow the study protocol.
Locations
Other Locations
China
Department ofNuclear Medicine,Xijing Hospital, Fourth Military Medical University, Xi'an, China
RECRUITING
Xi'an, China
Contact Information
Primary
Ying Guo
guoying01192022@163.com
0086+15991459177
Backup
he rui Li
3099595564@qq.com
0086+17563734669
Time Frame
Start Date:2024-06-12
Estimated Completion Date:2025-11-07
Participants
Target number of participants:60
Treatments
Experimental: before-after study in the same patient
This is a prospective, open-label, single-center clinical study for renal cell carcinoma.~Sixty patients clinically suspected of having renal cell carcinoma and undergoing 68Ga-PSMA PET scans were included.~Qualified subjects underwent 68Ga-NOTA-RCCB6 PET scans within 7 days after completing the 68Ga-PSMA PET scan. Patient medical history was collected and laboratory tests were performed before the examination, and a biopsy or surgery was performed to obtain pathological results within 1 month after the examination, followed by a 6-month follow-up. The pathological results were used as the diagnostic gold standard.