Prediction of the Response Using Dynamic Contrast-enhanced Magnetic Resonance Imaging Before Intra-arterial Chemotherapy in Children With Retinoblastoma

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Observational
SUMMARY

Retinoblastoma is the most frequent intraocular tumor in children and represents 6% of all pediatric cancers before the age of 5 years-old. The outcome is now excellent with 95 to 97% of 5-years survival rate. Conservative treatments are being more and more used, and intra arterial chemotherapy is one of the adjuvant treatments proposed to the children. The treatment is efficient in most cases, but a small proportion of children will have an early progression after treatment. MRI is used for the diagnosis of retinoblastoma. We aim to find prognostic factors using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for early identification of children response to intra arterial chemotherapy.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• grade B to D retinoblastoma

• prescription of intra arterial chemotherapy

Locations
Other Locations
France
Fondation A De Rothschild
RECRUITING
Paris
Contact Information
Primary
Laurence Salomon, MD PhD
lsalomon@for.paris
0148036431
Backup
Augustin Lecler, MD
alecler@for.paris
Time Frame
Start Date: 2018-01-11
Estimated Completion Date: 2026-07
Participants
Target number of participants: 60
Related Therapeutic Areas
Sponsors
Leads: Fondation Ophtalmologique Adolphe de Rothschild

This content was sourced from clinicaltrials.gov